ChemicalBook > Product Catalog > Pharmaceutical intermediates > Heterocyclic compound > Pyrimidines > Chloropyrimidine > 4,6-Dichloro-1H-pyrazolo[3,4-d]pyrimidine
4,6-Dichloro-1H-pyrazolo[3,4-d]pyrimidine
4,6-Dichloro-1H-pyrazolo[3,4-d]pyrimidine Basic information
- Product Name:
- 4,6-Dichloro-1H-pyrazolo[3,4-d]pyrimidine
- Synonyms:
-
- 4,6-DICHLORO-1H-PYRAZOLO[3,4-D]PYRIMIDINE
- 4,6-dichloro-2H-pyrazolo[3,4-d]pyrimidine
- 1H-Pyrazolo[3,4-d]pyrimidine,4,6-dichloro-
- 4,6-dichloropyrrolo[2,3-d]pyrimidine
- 4,6-Dichloro-1H-pyrazole[3,4-D]pyriMidine
- 4,6-Dichloropyrazolo[3,4-d]pyriMidine
- 6-Dichloro-1H-pyrazolo[3
- 4,6-dichloro-1H-pyrazolo[3,4-d]pP03119ine
- CAS:
- 42754-96-1
- MF:
- C5H2Cl2N4
- MW:
- 189
- EINECS:
- 948-193-9
- Product Categories:
-
- Aromatics
- Heterocycles
- CHIRAL CHEMICALS
- Building Blocks
- Pyrazolo[x,x-y]pyridine
- Heterocycle-Pyrimidine series
- Mol File:
- 42754-96-1.mol
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4,6-Dichloro-1H-pyrazolo[3,4-d]pyrimidine Chemical Properties
- Melting point:
- 145 °C (decomp)
- Boiling point:
- 251.9±50.0 °C(Predicted)
- Density
- 2.02±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- solid
- pka
- 7.90±0.20(Predicted)
- color
- Off-white to yellow
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4,6-Dichloro-1H-pyrazolo[3,4-d]pyrimidine Usage And Synthesis
Chemical Properties
Yellow solid
Synthesis
To a solution of 2,4,6-trichloropyrimidine-5-carbaldehyde (19.0 g, 990 mmol) in methanol (300 mL) was added drop-wise a solution of hydrazine monohydrate (4.8 mL) in methanol (80 mL) at 0 °C followed by drop-wise addition of triethylamine (13 mL) in methanol (80 mL) at 0 °C. The mixture was stirred at the same temperature for 30 mm. The solvent was removed, and the residue was purified by flash chromatography to afford 4,6-Dichloro-1H-pyrazolo[3,4-d]pyrimidine (10.3 g, 62 % yield) as a yellow solid. ‘H NMR (CDC13, 400IVIHz): 11.56 (br, 1H), 8.43 (s, 1H). MS m/z 190.68 [M+1].
4,6-Dichloro-1H-pyrazolo[3,4-d]pyrimidine Preparation Products And Raw materials
Raw materials
4,6-Dichloro-1H-pyrazolo[3,4-d]pyrimidineSupplier
Changzhou Langyi Biomedical Technology Co., Ltd. Gold
- Tel
- 13706129682
- tiffany@langyupharm.com
Shanghai Titan Enterprise Development Co., Ltd Gold
- Tel
- 16621224781
- syy@titansci.com
Yantai Sheng Kai Lun Biological Products Co. , Ltd. Gold
- Tel
- 3119594100
- mark@sklnchem.cn
SiChuang NanBu Honesty Technology Co., Ltd.
- Tel
- 0838-5675166 15883665058
- nbcxkj@126.com
J & K SCIENTIFIC LTD.
- Tel
- 010-82848833 400-666-7788
- jkinfo@jkchemical.com
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4,6-Dichloro-1H-pyrazolo[3,4-d]pyrimidine(42754-96-1)Related Product Information
- 4,6-Dichloro-2-methylpyrimidine
- Pyrrolo[3,4-c]pyrazole-5(1H)-carboxylic acid, 4,6-dihydro-, 1,1-dimethylethyl ester
- 4,6-DICHLOROIMIDAZO[4,5-C]PYRIDINE
- 4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBONITRILE
- 4,6-Dichloro-5-iodopyrimidine
- 4,6-DIBROMOPYRIMIDINE
- 4,6-DIBROMOQUINOLINE
- 4,6-Dichloroquinazoline
- 4,6-DICHLORO-2-METHYLQUINAZOLINE
- 4,6-DICHLOROQUINOLINE
- 4,6-DICHLOROPYRIDO[3,4-D]PYRIMIDINE
- ETHYL 4,6-DICHLORO-3-QUINOLINECARBOXYLATE
- 4,6-dichloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidine
- 4,6-DICHLORO-1H-PYRAZOLO[3,4-D]PYRIMIDINE
- ethyl 5,7-dichloro-1H-pyrazolo[4,3-d]pyrimidine-3-carboxylate
- 1-Phenyl-4,6-dichloro-1H-pyrazolo[3,4-d]pyrimidine
- 1-Methyl-4,6-dichloro-1H-pyrazolo[3,4-d]pyrimidine
- 2-(TERT-BUTYL)-3,7-DICHLORO-5-(TRIFLUOROMETHYL)PYRAZOLO[1,5-A]PYRIMIDINE