N-BUTYLMORPHOLINE Chemical Properties

Melting point:

-57.1°C

Boiling point:

78°C/22mmHg(lit.)

Density 

0.9068

refractive index 

1.4430-1.4470

storage temp. 

Sealed in dry,Room Temperature

form 

clear liquid

pka

7.66±0.10(Predicted)

color 

Colorless to Light yellow to Light orange

EPA Substance Registry System

Morpholine, 4-butyl- (1005-67-0)

Safety Information

RIDADR 

1993

RTECS 

QD8773000

HazardClass 

3

PackingGroup 

III

HS Code 

2934999090

Toxicity

rabbit,LD50,skin,1800mg/kg (1800mg/kg),SKIN AND APPENDAGES (SKIN): CORROSIVE: AFTER TOPICAL EXPOSURE,Acute Toxicity Data. Journal of the American College of Toxicology, Part B. Vol. 1, Pg. 13, 1990.

N-BUTYLMORPHOLINE Usage And Synthesis

Synthesis

General method: A mixture of ionic liquids (1-6) (0.1 g), morpholine (0.55 mmol) and 1-chlorobutane (0.5 mmol) was heated and reacted at 90°C for 3 hours under the protection of inert atmosphere. After completion of the reaction, the reaction mixture was diluted with aqueous NaHCO3 and extracted with ether (Et2O). The organic layers were combined and dried with anhydrous magnesium sulfate (MgSO4). Subsequently, the solvent was evaporated under reduced pressure to give the crude product. The crude product was characterized and analyzed by gas chromatography-mass spectrometry (GC-MS) and nuclear magnetic resonance (NMR) spectroscopy.

References

[1] Journal of Molecular Liquids, 2015, vol. 204, p. 210 - 215
[2] Synthetic Communications, 2014, vol. 44, # 5, p. 620 - 632

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