A 10
A 10 Basic information
- Product Name:
- A 10
- Synonyms:
-
- A 10
- N-(2,6-Dioxopiperidin-3-yl)benzeneacetamide
- Antineoplaston A10 NSC 620261
- NSC-648539
- Antineoplaston A10(b)
- Benzeneacetamide, N-[(3S)-2,6-dioxo-3-piperidinyl]-
- (S)-N-(2,6-Dioxopiperidin-3-yl)-2-phenylacetamide
- Inhibitor,Antineoplaston A10,inhibit,Ras,Endogenous Metabolite,Antineoplaston A-10,Antineoplaston A 10,Apoptosis
- CAS:
- 91531-30-5
- MF:
- C13H14N2O3
- MW:
- 246.26
- Mol File:
- 91531-30-5.mol
A 10 Chemical Properties
- Boiling point:
- 571.2±49.0 °C(Predicted)
- Density
- 1.27±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- DMSO: 250 mg/mL (1015.19 mM)
- pka
- 10.79±0.40(Predicted)
- form
- Solid
- color
- White to off-white
A 10 Usage And Synthesis
Uses
Antineoplaston A10 is an antineoplaston that inhibits the growth of human hepatoma cells by inducing apoptosis. Antineoplaston A10 can be used in the study of liver cancer and breast cancer[1][2].
in vivo
Antineoplaston A10 (0-600 mg/kg; p.o.; 6 days per week for 5 weeks) dose-dependently inhibits the growth of HepG2 and HLE cells in mice and dose-dependently increases the incidence of apoptotic cells in xenograft mice[1].
| Animal Model: | Balb/c athymic (nu+/nu+) female mice with hepatocellular carcinoma xenografts[1]. |
| Dosage: | 0, 150, 300 and 600 mg/kg |
| Administration: | Oral gavage (p.o.) 6 days per week for 5 weeks |
| Result: | Reduced the expression of bcl-2 in the cytoplasm, and the bcl-2 positive cell rates decreased to 82.9, 69.4 and 56.3%, respectively. Increased the expression of p53 in the nucleus, and the p53 positive cell rates increased to 20.6%, 36.2 and 60.5%, respectively. |
References
[1] Qu XJ, et al. Induction of apoptosis in human hepatocellular carcinoma cells by synthetic antineoplaston A10. Anticancer Res. 2007 Jul-Aug;27(4B):2427-31. PMID:17695534
[2] Tsuda, et al. "Inhibitory effect of antineoplaston A-10 on breast cancer transplanted to athymic mice and human hepatocellular carcinoma cell lines." The Kurume Medical Journal 37.2 (1990): 97-104. DOI:10.2739/kurumemedj.37.97
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