3-Bromo-2-chloro-5-(trifluoromethyl)pyridine Chemical Properties

Melting point:

28-32℃

Boiling point:

210.5±35.0 °C(Predicted)

Density 

1.804±0.06 g/cm3(Predicted)

Flash point:

98°(208°F)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

pka

-3.34±0.10(Predicted)

form 

Solid

color 

Pale yellow to pale brown

CAS DataBase Reference

71701-92-3

Safety Information

Hazard Codes 

Xi,T

Risk Statements 

25-36/37/38

Safety Statements 

7/9-22-24/25-26-36/37-38-45-51

RIDADR 

UN 2811 6.1 / PGIII

WGK Germany 

3

HazardClass 

IRRITANT

HazardClass 

6.1

HS Code 

2933399990

3-Bromo-2-chloro-5-(trifluoromethyl)pyridine Usage And Synthesis

Synthesis

A mixture of 3-bromo-5-(trifluoromethyl)pyridin-2-ol (37.75g, 0.16 mol) and phosphorus(lll) oxychloride (POCI3; 75 mL) is stirred at 1000C for 5 hours. After cooling to room temperature, the mixture is poured into ice-water and extracted with CH2CI2 twice. The combined organic layer is washed with NaHCO3 aq., brine, dried over MgSO4, filtered, and concentrated in vacuo. The crude mixture is purified by flash column chromatography to give 3-bromo-2-chloro-5-trifluoromethylpyridine (31.90 g, 79 % yield) as a white solid.

References

[1] Patent: WO2007/73934, 2007, A1. Location in patent: Page/Page column 75
[2] Patent: WO2008/58961, 2008, A1. Location in patent: Page/Page column 44; 45
[3] Patent: WO2008/58967, 2008, A1. Location in patent: Page/Page column 43; 44

3-Bromo-2-chloro-5-(trifluoromethyl)pyridine(71701-92-3)Related Product Information

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