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Methylophiopogonanone A

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Methylophiopogonanone A Basic information

Product Name:
Methylophiopogonanone A
Synonyms:
  • Methylophiopogonanone A
  • (3R)-3-(1,3-benzodioxol-5-ylmethyl)-5,7-dihydroxy-6,8-dimethyl-2,3-dihydrochromen-4-one
  • Methylophiopogonanone A(R-Methylophiopogonanone A)
  • 8-Methylophiopogonanone A
  • (3R)-3-(1,3-Benzodioxol-5-ylmethyl)-2,3-dihydro-5,7-dihydroxy-6,8-dimethyl-4H-1-benzopyran-4-one
  • R-Methylophiopogonanone A
  • Methylophiopogonanone A (MO-A)
  • 4H-1-Benzopyran-4-one, 3-(1,3-benzodioxol-5-ylmethyl)-2,3-dihydro-5,7-dihydroxy-6,8-dimethyl-, (3R)-
CAS:
74805-92-8
MF:
C19H18O6
MW:
342.34
Product Categories:
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
Mol File:
74805-92-8.mol
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Methylophiopogonanone A Chemical Properties

Boiling point:
580.1±50.0 °C(Predicted)
Density 
1.410
storage temp. 
2-8°C
solubility 
Soluble in chloroform and methanol;
form 
powder
pka
8.24±0.40(Predicted)
color 
Light yellow
Water Solubility 
insoluble in water
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Methylophiopogonanone A Usage And Synthesis

Description

Methylophiopogonanone A is a homoisoflavonoid that has been found in O. japonicus roots and has diverse biological activities. It increases the uptake of rosuvastatin (Item Nos. 12029 | 18813) and atorvastatin in HEK293T cells expressing human organic anion transporting polypeptide 1B1 (OATP1B1; EC50s = 11.33 and 6 μM, respectively). Methylophiopogonanone A scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; ) and ABTS radicals in cell-free assays. In vivo, methylophiopogonanone A (10 mg/kg) decreases body weight gain and reduces serum and hepatic lipid levels in a rat model of high-fat diet-induced hyperlipidemia. It also reduces infarct size and myocardial apoptosis in mouse model of ischemia-reperfusion injury induced by transient occlusion of the left anterior descending coronary artery.

Definition

ChEBI: Methylophiopogonanone A is a homoflavonoid.

target

MMP(e.g.TIMP)

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