Azlocillin sodium
Azlocillin sodium Basic information
- Product Name:
- Azlocillin sodium
- Synonyms:
-
- sodium [2S-[2alpha,5alpha,6beta(S*)]]-3,3-dimethyl-7-oxo-6-[[[[(2-oxoimidazolidin-1-yl)carbonyl]amino]phenylacetyl]amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
- Sterile Azlocillin sodium
- AZLOCILLINE SODIUM
- d-α-([imidazolidin-2-on-1-yl]carbonylamino)benzylpenicillin
- sodium azlocillin
- sodium [2s-[2a,5a,6b(s*)]]-3,3-dimethyl-7-oxo-6-[[[[(2-oxoimidazolidin-1-yl)carbonyl]amino]phenylacetyl]amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
- 2-oxo-1-imidazolidinyl)carbonyl)amino)phenylacetyl)amino)-,monosodiumsalt,(
- 5-alpha,6-beta(s*)))-2s-(2-alph
- CAS:
- 37091-65-9
- MF:
- C20H22N5NaO6S
- MW:
- 483.47
- EINECS:
- 253-347-7
- Product Categories:
-
- Active Pharmaceutical Ingredients
- Miscellaneous
- 37091-65-9
- Mol File:
- 37091-65-9.mol
Azlocillin sodium Chemical Properties
- Melting point:
- >199oC (dec.)
- Flash point:
- >110°(230°F)
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- H2O: soluble50mg/mL
- form
- powder
- color
- White to Off-White
- Water Solubility
- Freely soluble in water
- Stability:
- Hygroscopic
- CAS DataBase Reference
- 37091-65-9(CAS DataBase Reference)
Safety Information
- Hazard Codes
- Xn
- Risk Statements
- 42/43
- Safety Statements
- 36
- WGK Germany
- 3
- RTECS
- XH9250000
- Toxicity
- mouse,LD50,intramuscular,15420mg/kg (15420mg/kg),LUNGS, THORAX, OR RESPIRATION: DYSPNEABEHAVIORAL: TREMORBEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX),Antibiotiki i Meditsinskaya Biotekhnologiya. Antibiotics and Medical Biotechnology. Vol. 32, Pg. 453, 1987.
Azlocillin sodium Usage And Synthesis
Originator
Securopen,Bayer,W. Germany,1977
Uses
Antibacterial;Bacterial transpeptidase inhibitor
Uses
Azlocillin sodium is a semisynthetic penicillin and is a potent 1-lactam antibiotic. It is often used against Pseudomonas aeruginosa and has been used to develop novel antibiotic quantitation techniques.
Definition
ChEBI: Azlocillin sodium is an organic sodium salt. It contains an azlocillin(1-).
Manufacturing Process
3.8 parts by weight of D-(-)-α-[(imidazolidin-2-on-1-yl)carbonylamino]phenylacetic acid were dissolved in 65 parts by volume of dichloromethane. 2.7 parts by weight of 1-methyl-2-chloro-δ1-pyrrolinium chloride were added, and after cooling to -10°C 2.0 parts by volume of triethylamine were added gradually. This reaction mixture was then stirred for one hour at -5°C (mixture A). 4.0 parts by weight of 6-aminopenicillanic acid in 80 parts by volume of dichloromethane were treated with 4.4 parts by volume of triethylamine and 4.0 parts by weight of anhydrous sodium sulfate and then stirred for two hours at room temperature. After filtration, the solution was cooled to -20°C and combined with the mixture A. The reaction mixture was left to reach 0°C of its own accord, and was then stirred for a further hour at 0°C. The solvent was removed in a rotary evaporator, the residue was dissolved in water, and the solution was covered with a layer of ethyl acetate and acidified with dilute hydrochloric acid at 0° to 5°C, while stirring, until pH 1.5 was reached. The organic phase was then separated off, washed with water, dried over magnesium sulfate while cooling, and filtered, and after dilution with an equal amount of ether the sodium salt of the penicillin was precipitated from the filtrate by adding a solution of sodium 2-ethylcaproate dissolved in ether containing methanol. Yield: 1.3 parts by weight.
brand name
Azlin (Bayer).
Therapeutic Function
Antibacterial
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Azlocillin sodium(37091-65-9)Related Product Information
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