4-Acetylpyridine Chemical Properties

Melting point:

13-16 °C(lit.)

Boiling point:

212 °C(lit.)

Density 

1.095 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.529(lit.)

Flash point:

>230 °F

storage temp. 

Inert atmosphere,Room Temperature

solubility 

Chloroform, Ethyl Acetate

pka

pK1: 3.505(+1) (25°C)

form 

Liquid

Specific Gravity

1.110 (20/4℃)

color 

brown-yellowish

Water Solubility 

insoluble

BRN 

107629

InChIKey

WMQUKDQWMMOHSA-UHFFFAOYSA-N

LogP

0.480

CAS DataBase Reference

1122-54-9(CAS DataBase Reference)

NIST Chemistry Reference

Ethanone, 1-(4-pyridinyl)-(1122-54-9)

EPA Substance Registry System

4-Acetylpyridine (1122-54-9)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-36/38-22

Safety Statements 

26-36-37/39

WGK Germany 

3

RTECS 

OB5426000

F 

8

Hazard Note 

Irritant

TSCA 

Yes

HS Code 

29333999

MSDS

• Language:English Provider:Methyl 4-pyridyl ketone
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

4-Acetylpyridine Usage And Synthesis

Chemical Properties

clear light yellow to brownish liquid

Uses

4-Acetylpyridine is a acetylated pyridine used in the preparation of nitrogen containing bicyclic heterocycles and other organic compounds. 4-Acetylpyridine is also present in mainstream cigarette smo ke.

Uses

4-acetylpyridine on reaction with - and 4-formylpyridine (H3FoPyS, H4FoPyS) yields semicarbazones. Reaction of acetylpyridine with thiophene-2-carboxaldehyde afforded the 2-chloro-6-ethoxy-4-β-(2-thienyl)acryloylpyridine, which was reacted with malononitrile in refluxing ethanol in the presence of piperidine as a catalyst to afford the cyanoaminopyrane derivative.

General Description

Dark amber liquid.

Air & Water Reactions

Soluble in water.

Reactivity Profile

4-Acetylpyridine is incompatible with strong oxidizing agents and strong reducing agents. . Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.

Fire Hazard

4-Acetylpyridine is probably combustible.

4-Acetylpyridine(1122-54-9)Related Product Information

• Methyl salicylate
• Methyl acetate
• Pyridine
• Acetylsalicylic acid
• Tribenuron methyl
• Acetylcholine
• Acetylspiramycin
• N-ACETYL-L-TYROSINE ETHYL ESTER
• Sulfasalazine
• Thiophanate-methyl
• Acetaminophen
• Chromium picolinate
• Kresoxim-methyl
• METSULFURON METHYL
• Acetylacetone
• Methyl
• 3-ACETYLPYRIDINE,beta-Acetylpyridine,3-ACETYLPYRIDINE 99+%
• 2-Acetylpyridine ,98%,2-ACETYLPYRIDINE