GS 389 Chemical Properties

Melting point:

200-203 °C

Boiling point:

454.0±45.0 °C(Predicted)

Density 

1.108±0.06 g/cm3(Predicted)

pka

8.75±0.40(Predicted)

GS 389 Usage And Synthesis

Description

GS 389 is a novel tetrahydroisoquinoline analog. GS-389 significantly increased cGMP levels in the rat aorta and inhibited cGMP phosphodiesterase from the rabbit brain. It has vasorelaxant properties.

Uses

GS 389 ((±)-O,O-Dimethylcoclaurine) is a tetrahydroisoquinoline. GS-389 inhibites Cyclic AMP and cyclic AMP dependent phosphodiesterases from rat atrial and ventricular tissue. GS-389 relaxes the contraction induced by phenylephrine and high K+ in rat aortic rings[1].

References

[1] Chang KC, et al. Different pharmacological characteristics of structurally similar benzylisoquinoline analogs, papaverine, higenamine, and GS 389, on isolated rat aorta and heart. Can J Physiol Pharmacol. 1994;72(4):327-334. DOI:10.1139/y94-049

GS 389(41498-37-7)Related Product Information

• ISOCORYDINE HYDROCHLORIDE
• DL-LAUDANOSINE
• Tetrahydropapaverine hydrochloride
• CURINE
• DAURICINE
• BERBAMINE
• BOLDINE DIMETHYL ETHER
• D-TUBOCURARINE CHLORIDE
• TETRAHYDROPALMATINE HYDROCHLORIDE
• Corydaline
• OXYACANTHINE HYDROCHLORIDE
• Cepharanthine
• ISOCORYDINE HYDROCHLORIDE
• DL-6'-BROMOLAUDANOSIN
• L-TETRANDRINE
• PAVINE HCL
• AKOS 236-50
• (+)-MENISPERINE IODIDE