Benidipine Chemical Properties

Boiling point:

625.2±55.0 °C(Predicted)

Density 

1.29±0.1 g/cm3(Predicted)

pka

pKa 7.34(H2O(long extrapolation) ) (Uncertain)

Water Solubility 

316μg/L at 25℃

LogP

4.61

CAS DataBase Reference

105979-17-7(CAS DataBase Reference)

Benidipine Usage And Synthesis

Uses

Benidipine (CAS# 105979-17-7) is a 1,4-dihydropyridine and a calcium channel antagonist. Antihypertensive.

Enzyme inhibitor

This oral, once-daily antihypertensive agent (FW = 505.57 g/mol; CAS 105979-17-7), also known by its code name KW-3049, trade name Coniel?, and systematic name O -methyl,O -[(3R)-1-(phenylmethyl)piperidin-3-yl] 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, is a dihydropyridine-class calcium ion blocker that is effective against L-, N-, and T-channels, with potent and selective inhibitory action on cardiac slow calcium channels. Benidipine bound stereospecifically to nitrendipine binding sites of rat myocardium with high affinity (Ki = 0.13 nM) and to the rat brain a1-adrenergic receptor (Ki = 1.2 μM). KW-3049 exhibited no remarkable binding affinity to a2 adrenergic, b-adrenergic, D2 dopamine, H1 histamine, S2 serotonin, A1 adenosine, A2 adenosine and muscarinic cholinergic receptors at 100 μM.

Benidipine(105979-17-7)Related Product Information

• Dimethyl sulfoxide
• Benzyl chloride
• Dimethyl fumarate
• N,N-Dimethylformamide
• Benzyl isocyanate
• Benzyl alcohol
• Haloperidol
• Benzyltrimethylammonium chloride
• Benzyl nicotinate
• ETHANE
• Benzyl benzoate
• Chlorodimethylphenylsilane
• Benzyltriethylammonium chloride
• Diphenoxylate
• Benidipine hydrochloride
• 2-(Diethylamino)ethyl methacrylate
• 1-Benzyl-3-piperidinol hydrochloride
• Nitrendipine