protosappanin A Chemical Properties

Melting point:

254-255 °C

Boiling point:

613.1±55.0 °C(Predicted)

Density 

1.476±0.06 g/cm3(Predicted)

storage temp. 

4°C, away from moisture and light

solubility 

Soluble in DMSO

form 

Solid

pka

9.01±0.20(Predicted)

color 

White to off-white

protosappanin A Usage And Synthesis

Description

Protosappanin A (PTA), an immunosuppressive ingredient and major biphenyl compound isolated from Caesalpinia sappan L, suppresses JAK2/STAT3-dependent inflammation pathway through down-regulating the phosphorylation of JAK2 and STAT3.

Uses

Protosappanin A (PTA), an immunosuppressive ingredient and major biphenyl compound isolated from Caesalpinia sappan L, suppresses JAK2/STAT3-dependent inflammation pathway through down-regulating the phosphorylation of JAK2 and STAT3[1].

Definition

ChEBI: Protosappanin A is a member of catechols. It has a role as a metabolite.

IC 50

JAK2; STAT3

References

[1] Wang LC, et al. Protosappanin A exerts anti-neuroinflammatory effect by inhibiting JAK2-STAT3 pathway in lipopolysaccharide-induced BV2 microglia. Chin J Nat Med. 2017 Sep;15(9):674-679. DOI:10.1016/S1875-5364(17)30096-1
[2] Zeng KW, et al. Protosappanin A inhibits oxidative and nitrative stress via interfering the interaction of transmembrane protein CD14 with Toll-like receptor-4 in lipopolysaccharide-induced BV-2 microglia. Int Immunopharmacol, 2012, 14(4): 558- 569. DOI:10.1016/j.intimp.2012.09.004

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