methyl 2-tetradecylglycidate
methyl 2-tetradecylglycidate Basic information
- Product Name:
- methyl 2-tetradecylglycidate
- Synonyms:
-
- methyl 2-tetradecylglycidate
- 2-Tetradecyloxirane-2-carboxylic acid methyl ester
- 2-Tetradecyloxiranecarboxylic acid methyl ester
- MCN-3716
- Methyl palmoxirate
- Methyl parmoxirate
- McN3716 (Methyl palmoxirate
- NSC359682)
- CAS:
- 69207-52-9
- MF:
- C18H34O3
- MW:
- 298.46
- Mol File:
- 69207-52-9.mol
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methyl 2-tetradecylglycidate Chemical Properties
- Melting point:
- 44-46 °C
- Boiling point:
- 361.4±17.0 °C(Predicted)
- Density
- 0.944±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Solid
- color
- White to off-white
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methyl 2-tetradecylglycidate Usage And Synthesis
Uses
Antidiabetic.
Uses
Methyl Palmoxirate is an inhibitor of fatty acid oxidation.
in vivo
Inhibition of brain mitochondrial β-oxidation by McN3716 (Methyl palmoxirate, MEP) significantly reduces the levels of all measured HETE and epoxytrienoic acids (EET), nonenzymatic auto-oxidative metabolites of ARA, by 23% to 44% and 32% to 50% compared with vehicle-injected rats, respectively, except for 15-HETE which was unaffected. There is a significant 34% reduction in the level of 6-keto-PGF1α, a byproduct of PGI2 (prostacyclin) in McN3716-treated rats. Similarly, the brain level of hydroxyeicosapentaenoic acids, nonenzymatic auto-oxidative metabolites of EPA, is reduced by 35% to 76% upon McN3716 treatment relative to vehicle[1].
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