2-amino-4-phosphonobutyric acid Chemical Properties

Melting point:

229-231 °C(Solv: ethanol (64-17-5); water (7732-18-5))

Boiling point:

491.7±55.0 °C(Predicted)

Density 

1.628±0.06 g/cm3(Predicted)

storage temp. 

Store at RT

solubility 

Water:9.15(Max Conc. mg/mL);50.0(Max Conc. mM)

form 

White solid.

pka

2.19±0.10(Predicted)

color 

White to off-white

Water Solubility 

Soluble to 50 mM in water

2-amino-4-phosphonobutyric acid Usage And Synthesis

Description

DL-AP4 is a broad-spectrum glutamatergic antagonist. DL-AP4 (2.5 mM) inhibits electrically stimulated synaptic transmission in rabbit hippocampal slices. It also depresses depolarizations induced by NMDA , L-homocysteate, or kainate in isolated frog spinal cord when used at a concentration of 1 mM. DL-AP4 (0.2 mM) inhibits the accumulation of inositol induced by ibotenate , quisqualate, L-glutamate, and L-aspartate in rat hippocampal slices.

Uses

DL-2-Amino-4-phosphonobutanoic acid (AP4) is an amino-acid derivative reported to block cone signals in the rat retina. Improves learning and memory processes in passive and active avoidance situations in rats.

storage

Store at RT

References

[1] W. FROST WHITE. Glutamate as transmitter of hippocampal perforant path[J]. Nature, 1977, 270 5635: 356-357. DOI: 10.1038/270356a0
[2] R.H. EVANS. ANTAGONISM OF EXCITATORY AMINO ACID-INDUCED RESPONSES AND OF SYNAPTIC EXCITATION IN THE ISOLATED SPINAL CORD OF THE FROG[J]. British Journal of Pharmacology, 1979, 67 4: 591-603. DOI: 10.1111/j.1476-5381.1979.tb08706.x
[3] F. NICOLETTI. Coupling of Inositol Phospholipid Metabolism with Excitatory Amino Acid Recognition Sites in Rat Hippocampus[J]. Journal of Neurochemistry, 1986, 46 1: 40-46. DOI: 10.1111/j.1471-4159.1986.tb12922.x

2-amino-4-phosphonobutyric acid(6323-99-5)Related Product Information

• 7-CHLORO-4-MERCAPTOQUINOLINE-2-CARBOXYLIC ACID HCL
• Memantine HCl
• D-Cycloserine
• N-Methyl-D-aspartic acid
• Licostinel
• Cycloleucine
• Quinolinic acid
• Spermidine trihydrochloride
• (R)-CPP
• Synthalin sulfate
• DL-2-AMINO-5-PHOSPHONOPENTANOIC ACID
• D-AP5
• 5,7-DICHLOROKYNURENIC ACID SODIUM SALT
• O-Phospho-L-serine
• L-701,252