2-amino-4-phosphonobutyric acid Chemical Properties

Melting point:

229-231 °C(Solv: ethanol (64-17-5); water (7732-18-5))

Boiling point:

491.7±55.0 °C(Predicted)

Density 

1.628±0.06 g/cm3(Predicted)

storage temp. 

Store at RT

solubility 

Water:9.15(Max Conc. mg/mL);50.0(Max Conc. mM)

form 

White solid.

pka

2.19±0.10(Predicted)

Water Solubility 

Soluble to 50 mM in water

2-amino-4-phosphonobutyric acid Usage And Synthesis

Description

DL-AP4 is a broad-spectrum glutamatergic antagonist. DL-AP4 (2.5 mM) inhibits electrically stimulated synaptic transmission in rabbit hippocampal slices. It also depresses depolarizations induced by NMDA , L-homocysteate, or kainate in isolated frog spinal cord when used at a concentration of 1 mM. DL-AP4 (0.2 mM) inhibits the accumulation of inositol induced by ibotenate , quisqualate, L-glutamate, and L-aspartate in rat hippocampal slices.

Uses

DL-2-Amino-4-phosphonobutanoic acid (AP4) is an amino-acid derivative reported to block cone signals in the rat retina. Improves learning and memory processes in passive and active avoidance situations in rats.

storage

Store at RT

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