scopolin
scopolin Basic information
- Product Name:
- scopolin
- Synonyms:
-
- Scopoletin 7-O-Glucoside
- CPD-678
- 6-Methoxy-7-(beta-D-glucopyranosyloxy)coumarin
- 6-Methoxycoumarin 7-O-beta-D-glucoside
- 7-(beta-D-Glucopyranosyloxy)-6-methoxy-2H-1-benzopyran-2-one
- 7-(beta-D-Glucopyranosyloxy)-6-methoxycoumarin
- 5Mg
- Murrayin
- CAS:
- 531-44-2
- MF:
- C16H18O9
- MW:
- 354.31
- Mol File:
- 531-44-2.mol
scopolin Chemical Properties
- Melting point:
- 217℃
- Boiling point:
- 650.2±55.0 °C(Predicted)
- Density
- 1.552
- storage temp.
- 2-8°C
- solubility
- Soluble in DMSO
- form
- powder
- pka
- 12.71±0.70(Predicted)
- color
- White
- Major Application
- food and beverages
- InChI
- InChI=1/C16H18O9/c1-22-9-4-7-2-3-12(18)23-8(7)5-10(9)24-16-15(21)14(20)13(19)11(6-17)25-16/h2-5,11,13-17,19-21H,6H2,1H3/t11-,13-,14+,15-,16-/s3
- InChIKey
- SGTCGCCQZOUMJJ-ONCUFOQVNA-N
- SMILES
- O([C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)C1C=C2OC(=O)C=CC2=CC=1OC |&1:1,2,3,5,7,r|
scopolin Usage And Synthesis
Chemical Properties
Soluble in methanol, ethanol, DMSO and other organic solvents, derived from diclofenac, dingongteng, scopolamine root, ningxia wolfberry, mulberry tree.
Uses
Scopoletin 7-O-glucoside is a derivative of Scopoletin (S200500), a common constituent found in a variety of plants that has potential to regulate hyperthyroidism in rats. Scopoletin 7-O-glucoside is a compound that is obtained from the methanolic extract of the fresh underground parts of the flower Scopolia japonica.
Definition
ChEBI: A member of the class of coumarins that is scopoletin attached to a beta-D-glucopyranosyl residue at position 7 via a glycosidic linkage.
in vivo
Scopolin (0.02% (w/w) in HFD diet, 8 weeks) decreases the body weight gain, and alleviates hepatic steatosis in HFD-fed mice[2].
Scopolin (2 μmol, icv) increases the extracellular acetylcholine concentration in rat brain to about 300% compared to basal release[3].
Scopolin (50, 100 mg/kg, i.p.) inhibits adjuvant-induced arthritis by inhibiting inflammation and angiogenesis in rats[4].
| Animal Model: | HFD-fed C57BL/6?N mice[2] |
| Dosage: | 0.02% (w/w) in HFD diet (equivalent to 20?mg/kg body weight) |
| Administration: | Supplemented in diet, 8 weeks |
| Result: | Reversed the HFD-induced hepatic TG, cholesterol, and fatty acid accumulation by 35%, 49%, and 35%, respectively. Reversed the HFD-induced decrease in plasma adiponectin levels by 76%, and reduced the increased plasma MCP-1, TNFα, and IL-6 levels. Restored HFD-induced downregulation of SIRT1 activity. |
| Animal Model: | Adjuvant-induced arthritis (AIA) rats[4] |
| Dosage: | 50, 100 mg/kg |
| Administration: | i.p. |
| Result: | Inhibited inoculated and non-inoculated paw swelling and articular index scores. Reduced new blood vessels, and reduced IL-6, VEGF and FGF-2 expressions in rat synovial tissues. |
target
VEGFR | IL Receptor | AChR | Antifection
IC 50
SIRT1
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