1-methoxyphaseollidin Chemical Properties

Boiling point:

521.7±50.0 °C(Predicted)

Density 

1.270±0.06 g/cm3(Predicted)

pka

9.15±0.20(Predicted)

form 

Solid

color 

White to off-white

1-methoxyphaseollidin Usage And Synthesis

Uses

1-Methoxyphaseollidin, a flavonoid compound, is a lysoPAF acetyltransferase inhibitor, with an IC50 of 48 μM. 1-Methoxyphaseollidin exhibits anti-H.pylori activity against the CLAR and AMOX-resistant strain as well as four CLAR (AMOX)-sensitive strains[1][2][3].

Definition

ChEBI: 1-Methoxyphaseollidin is a member of pterocarpans.

IC 50

Human Endogenous Metabolite

References

[1] Fukai T, et, al. Anti-Helicobacter pylori flavonoids from licorice extract. Life Sci. 2002 Aug 9;71(12):1449-63. DOI:10.1016/s0024-3205(02)01864-7
[2] Nagumo S, et, al. Inhibition of lysoPAF acetyltransferase activity by components of licorice root. Biol Pharm Bull. 1999 Oct;22(10):1144-6. DOI:10.1248/bpb.22.1144
[3] Sinha SK, et, al. Potential Leads from Liquorice Against SARS-CoV-2 Main Protease using Molecular Docking Simulation Studies. Comb Chem High Throughput Screen. 2021;24(4):591-597. DOI:10.2174/1386207323999200817103148

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