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nardosinone

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nardosinone Basic information

Product Name:
nardosinone
Synonyms:
  • nardosinone
  • (3aR)-1,3aβ,4,7,8,9,9a,9bβ-Octahydro-1,1,9β,9aβ-tetramethyl-5H-naphtho[2,1-c][1,2]dioxol-5-one
  • 1,1,9β,9aβ-Tetramethyl-3aβ,7,8,9,9a,9bβ-hexahydro-1H-naphtho[2,1-c][1,2]dioxole-5(4H)-one
  • (3aR,9R,9aR,9bS)-1,3a,4,7,8,9,9a,9b-Octahydro-1,1,9,9a-tetramethyl-5H-naphtho[2,1-c][1,2]dioxol-5-one
  • Nardosinone, 98%, from Nardostachys jatamansi DC.
  • 5H-Naphtho[2,1-c][1,2]dioxol-5-one,1,3a,4,7,8,9,9a,9b-octahydro-1,1,9,9a-tetramethyl-, (3aR,9R,9aR,9bS)-
  • (3aR,9R,9aR,9bS)-1,1,9,9a-Tetramethyl-3a,4,7,8,9,9a-hexahydro-1H-naphtho[2,1-c][1,2]dioxol-5(9bH)-one
  • Nardosinone-RM
CAS:
23720-80-1
MF:
C15H22O3
MW:
250.33
Product Categories:
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
Mol File:
23720-80-1.mol
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nardosinone Chemical Properties

Melting point:
108-110℃
Boiling point:
330.2±32.0 °C(Predicted)
Density 
1.11
storage temp. 
-20°C
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Solid
color 
White to Off-White
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Safety Information

HS Code 
29145090
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nardosinone Usage And Synthesis

Uses

Nardosinone reduces neuronal injury and protects H9c2 cardiac cells from angiotensin II-induced hypertrophy which may give rise to heart failure. Enhancer of nerve growth factor (NGF).

Biological Activity

Nardosinone is a main active ingredient from medical plant Nardostachys jatamansi. Nardosinone exhibits varies pharmacological effects including anti-inflammatory and anti-hypertrophic in cardiomyocytes. Nardosinone enhances activity of the nerve growth factor and promotes neural stem cells proliferation and differentiation. The molecular mechanism of its activity remains unclear.

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Chembest Research Laboratories Limited
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