Basic information Safety Supplier Related

N 556

Basic information Safety Supplier Related

N 556 Basic information

Product Name:
N 556
Synonyms:
  • N 556
  • 5,5'-[[2-(Lysyloxy)propane-1,3-diyl]bisoxy]bis[4-oxo-4H-1-benzopyran-2-carboxylic acid ethyl]·2hydrochloride
  • KY-556
  • KY556,KY 556
CAS:
110816-78-9
MF:
C33H36N2O12.2ClH
MW:
725.571
Mol File:
110816-78-9.mol
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N 556 Chemical Properties

Melting point:
225-228 °C
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
Solid
color 
White to off-white
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N 556 Usage And Synthesis

Uses

KY-556 is a promising and orally-active pro-agent of disodium cromoglycate (DSCG) against allergic diseases.

in vivo

The oral anti-allergic effect of KY-556 (N-556) is investigated. N-556 (10-100 mg/kg, p.o.) inhibits dose-dependently the 48-hr homologous passive cutaneous anaphylaxis (PCA) in rats, and the duration of action is longer than that of intravenous Disodium cromoglycate (DSCG). N-556 (20 and 100 mg/kg once a day for 20 consecutive days, p.o.) tends to inhibit the histamine release from actively sensitized rat lung fragments. N-556 (100 mg/kg, p.o.) shows the prolongation of survival time in the rat systemic anaphylaxis. N-556 (100 mg/kg, p.o.) significantly inhibits the increased airway resistance in experimental asthma in rats[1].

References

[1] Nakamura S, et al. Effects of N-556 on experimental allergy models in rats. Arerugi. 1990 Dec;39(12):1621-8. PMID:2096808

N 556Supplier

MedChemexpress LLC
Tel
021-58955995
Email
sales@medchemexpress.cn
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Beijing xinyanhui pharmaceutical research and development co., LTD
Tel
13969155946
Email
1461866103@qq.com
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 15801484223;
Email
psaitong@jm-bio.com
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
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N 556(110816-78-9)Related Product Information