3-Acetylindole Chemical Properties

Melting point:

188-192 °C (lit.)

Boiling point:

284.68°C (rough estimate)

Density 

1.1202 (rough estimate)

refractive index 

1.6070 (estimate)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

DMSO; Dichloromethane; Methanol;

form 

Powder

pka

15.38±0.30(Predicted)

color 

Yellow to light brown

BRN 

122579

CAS DataBase Reference

703-80-0(CAS DataBase Reference)

NIST Chemistry Reference

Ethanone, 1-(1h-indol-3-yl)-(703-80-0)

Safety Information

Safety Statements 

22-24/25

WGK Germany 

3

RTECS 

OB4520000

HazardClass 

IRRITANT

HS Code 

29339990

MSDS

• Language:English Provider:3-Acetylindole
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

3-Acetylindole Usage And Synthesis

Chemical Properties

yellow to light brown powder

Uses

Reactant for preparation of:• ;Indole derivatives as antitumor agents1• ;Endothelin-1 antagonists2• ;Oncrasin-1 derivatives as inhibitors of the C-terminal domain of RNA polymerase II with antitumor activities3• ;Inhibitors of hepatitis C NS3/4A serine protease4• ;Antibacterial agens against MDR Staphylococcus aureus strains5• ;Antimalarial agents6• ;Anti-bovine viral diarrhea virus (BVDV) agents7• ;HIV-1 integrase inhibitors8• ;Inhibitors of NF-κB transcription regulation related to TNF-α cytokine release9

Uses

Reactant for preparation of:

• Indole derivatives as antitumor agents
• Endothelin-1 antagonists
• Oncrasin-1 derivatives as inhibitors of the C-terminal domain of RNA polymerase II with antitumor activities
• Inhibitors of hepatitis C NS3/4A serine protease
• Antibacterial agens against MDR Staphylococcus aureus strains
• Antimalarial agents
• Anti-bovine viral diarrhea virus (BVDV) agents
• HIV-1 integrase inhibitors
• Inhibitors of NF-κB transcription regulation related to TNF-α cytokine release

Uses

3-Acetylindole can be used as anti-fungal agents.

Purification Methods

Recrystallise the indole from MeOH or *C6H6 containing a little EtOH. The phenylureido derivative has m 154o. [Baker J Chem Soc 461 1946, Beilstein 21/8 V 297.]

3-Acetylindole(703-80-0)Related Product Information

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• Indometacin
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• (2-METHYL-1H-INDOL-3-YL)-OXO-ACETIC ACID ETHYL ESTER
• (1H-INDOL-3-YL)-OXO-ACETIC ACID ETHYL ESTER
• Indole-3-glyoxylic acid
• INDOLE-3-GLYOXYLAMIDE
• INDOLE-3-GLYOXYLYL CHLORIDE
• 1,3-DIACETYLINDOLE
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• 3-dimethylamino-1-(1H-indol-3-yl)propan-1-one
• N,N-Dipropyl-3-indoleglyoxylamide
• 1-(1H-INDOL-3-YL)-PROPAN-1-ONE
• 5-BENZYLOXYINDOLE-3-GLYOXYLAMIDE