phenacid
phenacid Basic information
- Product Name:
- phenacid
- Synonyms:
-
- phenacid
- 4-[Bis(2-chloroethyl)amino]benzeneacetic acid
- CB-1331
- NSC-71964
- p-[Bis(2-chloroethyl)amino]phenylacetic acid
- Phenylacetic acid mustard
- Phenylacetic acid Mustard-d8
- 2-[4-[bis(2-chloroethyl)amino]phenyl]acetic acid
- CAS:
- 10477-72-2
- MF:
- C12H15Cl2NO2
- MW:
- 276.16
- Mol File:
- 10477-72-2.mol
More
Less
phenacid Chemical Properties
- Melting point:
- 105 °C(Solv: benzene (71-43-2); pentane (109-66-0))
- Boiling point:
- 125°C (rough estimate)
- Density
- 1.2884 (rough estimate)
- refractive index
- 1.6070 (estimate)
- pka
- 3.86±0.10(Predicted)
More
Less
phenacid Usage And Synthesis
Uses
Phenylacetic Mustard is a nitrogen mustard analog and the active metabolite of Chlorambucil (C325050). It is used as a chemotherapeutic agent and aside from having clastogenic activity, it can also induce chromosome delay.
Safety Profile
Poison by intraperitoneal route. Experimental reproductive effects. Mutation data reported. Whenheated to decomposition it emits toxic fumes of Clí and NOx.
in vivo
Phenylacetic acid mustard (intraperitoneal?injection; 0-20 mg/kg; 15 days) shows consistently 1.8-1.9 times greater antitumour potency than CHL, it exhibits an ED15 value of 8.0 mg/kg[2].Phenylacetic acid mustard (intraperitoneal?injection; 0-20 mg/kg; single dose) cause 50% lethality at the dose 15.9 mg/kg[2].
| Animal Model: | Inbred male C3H/He mice[1] |
| Dosage: | 0 mg/kg; 5 mg/kg; 10 mg/kg; 20 mg/kg |
| Administration: | Intraperitoneal?injection; 15 days |
| Result: | Exhibited anti-tumor activities in vivo. |
phenacidSupplier
BOC Sciences
- Tel
- 16314854226
- info@bocsci.com
Shenzhen Polymeri Biochemical Technology Co., Ltd.
- Tel
- +86-400-002-6226 +86-13028896684;
- sales@rrkchem.com
Hefei Molake Biotechnology Co., Ltd.
- Tel
- 0551-66336380 18956014586
- 983438788@qq.com
Energy Chemical
- Tel
- 021-58432009 400-005-6266
- marketing1@energy-chemical.com
Hubei Nordina Biotechnology Co., Ltd.
- Tel
- 19371278702