N(4)-methylcytidine Chemical Properties

Melting point:

202-203 °C(Solv: ethanol (64-17-5))

Boiling point:

504.2±60.0 °C(Predicted)

Density 

1.69±0.1 g/cm3(Predicted)

storage temp. 

2-8°C(protect from light)

solubility 

Aqueous Acid (Slightly), DMSO (Slightly), Methanol (Slightly), Water (Slightly)

pka

13.48±0.70(Predicted)

form 

Solid

color 

Off-White to Beige

Stability:

Hygroscopic

N(4)-methylcytidine Usage And Synthesis

Description

N4-Methylcytidine is a nucleoside analogue that inhibits synthesis of human mitochondrial DNA by inhibiting bacterial enzyme uridine-cytidine kinase, which converts uridine to cytidine in the mitochondria. N4-Methylcytidine has been shown to be potent against viruses such as HIV and herpes simplex virus type 1 (HSV-1) in cell culture studies. This antiviral effect is due to the interference with viral dna replication and protein synthesis by preventing incorporation of uracil into dna and ribosomal RNA.

Definition

ChEBI: N4-Methylcytidine is a pyrimidine nucleoside.