stephanine Chemical Properties

Melting point:

155 °C

Boiling point:

463.6±45.0 °C(Predicted)

Density 

1.268±0.06 g/cm3(Predicted)

solubility 

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

form 

Cryst.

pka

7.03±0.20(Predicted)

stephanine Usage And Synthesis

Description

l-Stephanine is a potent and highly selective alpha 1 adrenoceptor blocker, inhibits anococcygeus muscle contraction induced by phenylephrine with pA2 values of 6.76. Stephanine and crebanine have high inhibitory activity against gram-positive animal pathogenic bacteria, with MIC values of 0.078-0.312g/l, but low inhibitory activity against gram-negative animal pathogenic bacteria, they also inhibit hyphal growth of the plant pathogens Cercospora kaki. 3. Stephanine, pseudopalmatine , tetrahydropalmatine , and xylopinine show significant antiplasmodial activities with IC(50) ranged from 2 uM to 53 uM.

target

Adrenergic Receptor | Antifection

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