Propitocaine hydrochloride
Propitocaine hydrochloride Basic information
- Product Name:
- Propitocaine hydrochloride
- Synonyms:
-
- 2-(propylamino)-o-propionotoluidide hydrochloride
- 2-(propylamino)-o-propionotoluididmonohydrochloride
- alpha-propylamine-2-methyl-propionanilidehydrochloride
- citanesthydrochloride
- l-67hydrochloride
- Prilocaine HCL //Prilocaine
- N-(o-tolyl)-2-(propylamino)propionamide hydrochloride
- Prilocaine hydrochloride,N-(2-Methylphenyl)-2-(propylamino)propanamide hydrochloride
- CAS:
- 1786-81-8
- MF:
- C13H21ClN2O
- MW:
- 256.77
- EINECS:
- 217-244-0
- Product Categories:
-
- Sodium channel
- Amines
- Active Pharmaceutical Ingredients
- Aromatics
- Intermediates & Fine Chemicals
- Pharmaceuticals
- RULIDE
- API
- Mol File:
- 1786-81-8.mol
Propitocaine hydrochloride Chemical Properties
- Melting point:
- 168-170°C
- storage temp.
- 2-8°C
- solubility
- Freely soluble in water and in ethanol (96 per cent), very slightly soluble in acetone
- color
- White to Off-White
- Merck
- 14,7743
- InChI
- InChI=1S/C13H20N2O.ClH/c1-4-9-14-11(3)13(16)15-12-8-6-5-7-10(12)2;/h5-8,11,14H,4,9H2,1-3H3,(H,15,16);1H
- InChIKey
- BJPJNTKRKALCPP-UHFFFAOYSA-N
- SMILES
- C1(=CC=CC=C1C)NC(=O)C(C)NCCC.Cl
- CAS DataBase Reference
- 1786-81-8(CAS DataBase Reference)
Propitocaine hydrochloride Usage And Synthesis
Chemical Properties
White Solid
Uses
antibacterial
Uses
Propitocaine hydrochloride is a local anesthetic of the amino amide type,it is often used in dentistry. Prilocaine is also often combined with lidocaine as a preparation for dermal anesthesia (lidocaine/pril ocaine or EMLA), for treatment of conditions like paresthesia.
Uses
Anesthetic (local).
Definition
ChEBI: The monohydrochloride salt of prilocaine.
brand name
Citanest (AstraZeneca).
Biological Functions
Prilocaine hydrochloride (Citanest) is an amide anesthetic whose onset of action is slightly longer than that of lidocaine; its duration of action is comparable. Prilocaine is 40% less toxic acutely than lidocaine, making it especially suitable for regional anesthetic techniques. It is metabolized by the liver to orthotoluidine, which when it accumulates, can cause conversion of hemoglobin (HB+++ to methemoglobin (HB+++. Oxygen transport is impaired in the presence of methemoglobinemia. Treatment involves the use of reducing agents, such as methylene blue, given intravenously, to reconvert methemoglobin to hemoglobin.
Contact allergens
Prilocaine in a local anesthetic of the amide group. It can induce allergic contact dermatitis, particularly from EMLA? cream.
Side effects
Common adverse reactions include bradycardia, hypotension, urticaria, edema, anaphylactoid reactions, lightheadedness, nervousness, euphoria, confusion, dizziness, drowsiness, tinnitus. The safety and effectiveness of prilocaine depend on proper dosage, correct technique, adequate precautions, and readiness for emergencies.
Propitocaine hydrochloride Supplier
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