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Propitocaine hydrochloride

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Propitocaine hydrochloride Basic information

Product Name:
Propitocaine hydrochloride
Synonyms:
  • 2-(propylamino)-o-propionotoluidide hydrochloride
  • 2-(propylamino)-o-propionotoluididmonohydrochloride
  • alpha-propylamine-2-methyl-propionanilidehydrochloride
  • citanesthydrochloride
  • l-67hydrochloride
  • Prilocaine HCL //Prilocaine
  • N-(o-tolyl)-2-(propylamino)propionamide hydrochloride
  • Prilocaine hydrochloride,N-(2-Methylphenyl)-2-(propylamino)propanamide hydrochloride
CAS:
1786-81-8
MF:
C13H21ClN2O
MW:
256.77
EINECS:
217-244-0
Product Categories:
  • Sodium channel
  • Amines
  • Active Pharmaceutical Ingredients
  • Aromatics
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • RULIDE
  • API
Mol File:
1786-81-8.mol
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Propitocaine hydrochloride Chemical Properties

Melting point:
168-170°C
storage temp. 
2-8°C
solubility 
Freely soluble in water and in ethanol (96 per cent), very slightly soluble in acetone
color 
White to Off-White
Merck 
14,7743
InChI
InChI=1S/C13H20N2O.ClH/c1-4-9-14-11(3)13(16)15-12-8-6-5-7-10(12)2;/h5-8,11,14H,4,9H2,1-3H3,(H,15,16);1H
InChIKey
BJPJNTKRKALCPP-UHFFFAOYSA-N
SMILES
C1(=CC=CC=C1C)NC(=O)C(C)NCCC.Cl
CAS DataBase Reference
1786-81-8(CAS DataBase Reference)
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Safety Information

WGK Germany 
3
RTECS 
UG5775000
HS Code 
29242990
Toxicity
man,LDLo,parenteral,12343ug/kg/1H (12.343mg/kg),BLOOD: HEMORRHAGE,Journal of Analytical Toxicology. Vol. 10, Pg. 75, 1986.
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Propitocaine hydrochloride Usage And Synthesis

Chemical Properties

White Solid

Uses

antibacterial

Uses

Propitocaine hydrochloride is a local anesthetic of the amino amide type,it is often used in dentistry. Prilocaine is also often combined with lidocaine as a preparation for dermal anesthesia (lidocaine/pril ocaine or EMLA), for treatment of conditions like paresthesia.

Uses

Anesthetic (local).

Definition

ChEBI: The monohydrochloride salt of prilocaine.

brand name

Citanest (AstraZeneca).

Biological Functions

Prilocaine hydrochloride (Citanest) is an amide anesthetic whose onset of action is slightly longer than that of lidocaine; its duration of action is comparable. Prilocaine is 40% less toxic acutely than lidocaine, making it especially suitable for regional anesthetic techniques. It is metabolized by the liver to orthotoluidine, which when it accumulates, can cause conversion of hemoglobin (HB+++ to methemoglobin (HB+++. Oxygen transport is impaired in the presence of methemoglobinemia. Treatment involves the use of reducing agents, such as methylene blue, given intravenously, to reconvert methemoglobin to hemoglobin.

Contact allergens

Prilocaine in a local anesthetic of the amide group. It can induce allergic contact dermatitis, particularly from EMLA? cream.

Side effects

Common adverse reactions include bradycardia, hypotension, urticaria, edema, anaphylactoid reactions, lightheadedness, nervousness, euphoria, confusion, dizziness, drowsiness, tinnitus. The safety and effectiveness of prilocaine depend on proper dosage, correct technique, adequate precautions, and readiness for emergencies.

Propitocaine hydrochloride Supplier

Shandong Mingfeng Pharmaceutical and Technology Co. Ltd Gold
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