3-Fluoropyridine-2-carboxylic acid Chemical Properties

Melting point:

154°C

Boiling point:

265.2±20.0 °C(Predicted)

Density 

1.419±0.06 g/cm3(Predicted)

storage temp. 

Inert atmosphere,2-8°C

pka

2.71±0.10(Predicted)

form 

powder

color 

White

InChI

InChI=1S/C6H4FNO2/c7-4-2-1-3-8-5(4)6(9)10/h1-3H,(H,9,10)

InChIKey

IRERRSXDWUCFIY-UHFFFAOYSA-N

SMILES

C1(C(O)=O)=NC=CC=C1F

CAS DataBase Reference

152126-31-3(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,Xn

HazardClass 

IRRITANT

HS Code 

2933399990

3-Fluoropyridine-2-carboxylic acid Usage And Synthesis

Uses

3-Fluoropyridine-2-carboxylic acid is mainly used as an intermediate in organic synthesis and medicinal chemistry. It is a synthetic intermediate of tridentate nitrogen ligands in pesticide molecules and transition metal catalytic reactions.

Synthesis

To a diethyl ether (50 ml) solution of 1,4-diazabicyclo[2.2.2]octane (1.15 g, 10.3 mmol) was slowly added n-butyllithium (2.6 M hexane solution, 3.95 ml, 10.3 mmol) dropwise at -78 °C. The reaction mixture was stirred at -20°C for 1 hr, then a diethyl ether (30 ml) solution of 3-fluoropyridine (1.00 g, 10.29 mmol) was added dropwise at -78°C. The resulting yellow suspension was stirred at -60°C for 1 hr and subsequently cooled to -78°C and an excess of dry ice was added. The reaction solution was slowly warmed to -10°C over a period of 20 min. The precipitate was collected by filtration and the residue was washed with ether to give pure 3-fluoropyridine-2-carboxylic acid (1.20 g, 8.51 mmol, 83% yield).

References

[1] Tetrahedron, 1998, vol. 54, # 42, p. 12859 - 12886
[2] Patent: WO2014/82737, 2014, A1. Location in patent: Page/Page column 38

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