VIP (6-28) (HUMAN, BOVINE, PORCINE, RAT)
VIP (6-28) (HUMAN, BOVINE, PORCINE, RAT) Basic information
- Product Name:
- VIP (6-28) (HUMAN, BOVINE, PORCINE, RAT)
- Synonyms:
-
- H-PHE-THR-ASP-ASN-TYR-THR-ARG-LEU-ARG-LYS-GLN-MET-ALA-VAL-LYS-LYS-TYR-LEU-ASN-SER-ILE-LEU-ASN-NH2
- PHE-THR-ASP-ASN-TYR-THR-ARG-LEU-ARG-LYS-GLN-MET-ALA-VAL-LYS-LYS-TYR-LEU-ASN-SER-ILE-LEU-ASN-NH2
- VIP (6-28) (HUMAN, BOVINE, PORCINE, RAT)
- VIP(6-28)(human, rat, porcine, bovine),FTDNYTRLRKQMAVKKYLNSILN?, >98%
- VIP(6-28)(HUMAN, RAT, PORCINE, BOVINE)?, >98%
- VIP (6-28) (HUMAN, RAT, PORCINE, BOVINE)
- VASOACTIVE INTESTINAL PEPTIDE (6-28) (HUMAN, BOVINE, PORCINE, RAT)
- VASOACTIVE INTESTINAL PEPTIDE (6-28), HUMAN, PORCINE, RAT
- CAS:
- 69698-54-0
- MF:
- C126H207N37O34S
- MW:
- 2816.28
- Product Categories:
-
- VIP and PACAP receptor
- Peptide Receptors
- Mol File:
- 69698-54-0.mol
VIP (6-28) (HUMAN, BOVINE, PORCINE, RAT) Chemical Properties
- storage temp.
- −20°C
- form
- Powder
- Water Solubility
- Soluble to 1 mg/ml in water
- Sequence
- H-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH2
MSDS
- Language:English Provider:SigmaAldrich
VIP (6-28) (HUMAN, BOVINE, PORCINE, RAT) Usage And Synthesis
Biological Activity
VIP(6-28)(human, rat, porcine, bovine) is a potent exogenous vasoactive intestinal peptide (VIP) antagonist.
in vitro
VIP (6-28) (HUMAN, BOVINE, PORCINE, RAT) is an effective VIP antagonist in the superior cervical ganglion (SCG) , and results obtained using this analog indicate that endogenous VIP can participate in a positive feedback loop in injured sympathetic neurons in which it enhances its own expression. VIP(6-28), when added to short-term cultures of adult SCG at a concentration of 10, 30, or 100 μM, reduces the increase in cAMP levels produced by stimulation with 10 μM VIP by 52, 64, or 81%, respectively. At any of these concentrations tested, VIP(6-28) by itself does not alter cAMP levels. In contrast to its ability to reduce the VIP-stimulated elevation in cAMP levels by 64%, the addition of 30 μM VIP(6-28) to culture medium does not significantly alter cAMP levels measured after stimulation of adult ganglia with either isoproterenol or forskolin (10 μM each). Similar results on the ability of VIP(6-28) to block VIP -stimulated increases in cAMP levels are obtained in neuron-enriched and in non-neuronal cell-en riched dissociated cultures.
target
VIP
VIP (6-28) (HUMAN, BOVINE, PORCINE, RAT)Supplier
- Tel
- 010-82848833 400-666-7788
- jkinfo@jkchemical.com
- Tel
- 821-50328103-801 18930552037
- 3bsc@sina.com
- Tel
- 21-61263452 13641803416
- ymbetter@glbiochem.com
- Tel
- 4401179829988
- customerservice@ascentscientific.co.uk
- Tel
- 021-54306202 13764082696;
- info@hanhongsci.com
VIP (6-28) (HUMAN, BOVINE, PORCINE, RAT)(69698-54-0)Related Product Information
- [D-P-CL-PHE(6),LEU(17)]-VASOACTIVE INTESTINAL PEPTIDE HUMAN, PORCINE, RAT
- VIP (GUINEA PIG)
- Hexanoyl-(Ala1?,Lys2??2?)-VIP
- H-LEU-MET-TYR-PRO-THR-TYR-LEU-LYS-OH
- VIP SULFOXIDE (HUMAN, BOVINE, PORCINE, RAT)
- PG 97-269
- (ALA11,22,28)-VIP (HUMAN, BOVINE, PORCINE, RAT)
- Aviptadil
- HIS-SER-ASP-ALA-VAL-PHE-THR-ASP-ASN-TYR-THR-ARG
- H-LYS-PRO-ARG-ARG-PRO-TYR-THR-ASP-ASN-TYR-THR-ARG-LEU-ARG-LYS-GLN-MET-ALA-VAL-LYS-LYS-TYR-LEU-ASN-SER-ILE-LEU-ASN-NH2
- THR-ARG-LEU-ARG-LYS-GLN-MET-ALA-VAL-LYS-LYS-TYR-LEU-ASN-SER-ILE-LEU-ASN-NH2
- VIP (10-28) (HUMAN, BOVINE, PORCINE, RAT)
- (D-PHE2)-VIP (HUMAN, BOVINE, PORCINE, RAT)
- VIP (3-28) (HUMAN, BOVINE, PORCINE, RAT)
- VIP (4-28) (HUMAN, BOVINE, PORCINE, RAT)
- VIP (D8J1V) Rabbit mAb (IHC Formulated)
- VIP (D8J1V) Rabbit mAb (IF Formulated)
- VIP (H-6)