3,6-dichloropyridazin-4-amine Chemical Properties

Melting point:

203 °C

Boiling point:

363.0±37.0 °C(Predicted)

Density 

1.606±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

form 

solid

pka

2.08±0.10(Predicted)

color 

Yellow-brown

InChI

InChI=1S/C4H3Cl2N3/c5-3-1-2(7)4(6)9-8-3/h1H,(H2,7,8)

InChIKey

HODYDVHWWMTUEL-UHFFFAOYSA-N

SMILES

C1(Cl)=NN=C(Cl)C=C1N

Safety Information

HS Code 

2933998090

3,6-dichloropyridazin-4-amine Usage And Synthesis

Synthesis

General procedure for the synthesis of 3,6-dichloropyridazin-4-amine from 3,4,6-trichloropyridazine: Example 24A: 3,4,6-Trichloropyridazine (25 g, 136 mmol) was added to a 500 mL stainless steel pressure flask containing 14.8 N ammonium hydroxide solution (200 mL). The reaction mixture was stirred at 75°C for 16 hours. Upon completion of the reaction, the mixture was cooled to room temperature and the solid product was collected by filtration to afford 17 g (76% yield) of the target compound 3,6-dichloropyridazin-4-amine. The product characterization data were as follows: 1H NMR (400 MHz, DMSO-d6) δ ppm 7.16 (s, 2H), 6.82 (s, 1H); MS (ESI+) m/z 164 (M+H)+.

References

[1] Journal of Organic Chemistry, 2014, vol. 79, # 21, p. 10311 - 10322
[2] Patent: US2017/15675, 2017, A1. Location in patent: Paragraph 1001
[3] Patent: US2009/163489, 2009, A1. Location in patent: Page/Page column 51
[4] Patent: US2014/349990, 2014, A1. Location in patent: Paragraph 1051; 1052
[5] Patent: WO2014/191896, 2014, A1. Location in patent: Page/Page column 217; 218

3,6-dichloropyridazin-4-amine(823-58-5)Related Product Information

• 3,6-DibroMo-4-Methyl-pyridazine
• 3,6-Dichloropyridazine
• 3,6-DICHLORO-4-(4-PHENYL-1-PIPERAZINYL)-PYRIDAZINE
• TERT-BUTYL (3,6-DICHLOROPYRIDAZIN-4-YL)METHYLCARBAMATE
• 3,6-DICHLORO-N-(4-METHOXYPHENYL)-4-PYRIDAZINAMINE
• 3,6-DICHLORO-4-(4-METHYL-1-PIPERAZINYL)-PYRIDAZINE
• 3,6-dichloropyridazin-4-amine
• 3,6-DICHLORO-N-METHYL-4-PYRIDAZINAMINE
• 3,5,6-TRICHLOROPYRIDAZIN-4-YLAMINE
• 3,6-DICHLORO-4-(1-PIPERIDINYL)PYRIDAZINE
• 4-(3,6-DICHLORO-4-PYRIDAZINYL)-MORPHOLINE