Oxyresveratrol Chemical Properties

Melting point:

201-202.5 °C

Boiling point:

523.8±30.0 °C(Predicted)

Density 

1.468±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

Ethyl Acetate (Slightly), Methanol

pka

9.14±0.10(Predicted)

form 

Solid

color 

Pale Yellow to Pale Beige

InChIKey

PDHAOJSHSJQANO-OWOJBTEDSA-N

CAS DataBase Reference

29700-22-9(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36

Safety Statements 

26-24/25

WGK Germany 

3

HS Code 

29072990

Oxyresveratrol Usage And Synthesis

Description

Oxyresveratrol is an effective tyrosinase inhibitor, and has anti-tussive and anti-asthmatic, antioxidant, anti-inflammatory and analgesic effects.

Chemical Properties

White powder

Uses

Oxyresveratrol is a natural hydroxystilbene with similar bioactivity to resveratrol. COX-1 inhibitor like resveratrol (R150000), anti-cancer agent.

Definition

ChEBI: Oxyresveratrol is a stilbenoid.

Biological Activity

Oxyresveratrol is neuroprotective and inhibits the apoptotic cell death in transient cerebral ischemia. It effectively scavenges H2O2, NO (IC50 = 45.3 μM), and the artificial free radical 2,2-diphenyl-l-picrylhydrazyl (IC50 = 28.9 μM)
In vitro:
1)oxyresveratrol exhibited more than 50% inhibition at 100 μM on L-tyrosine oxidation by murine tyrosinase activity.
2) oxyresveratrol showed an IC50 value of 52.7 μM on the enzyme activity.
3) oxyresveratrol works through reversible inhibition of tyrosinase activity rather than suppression of the expression and synthesis of the enzyme.
In vivo:
1) Oxyresveratrol (10 or 20 mg/kg) significantly reduced the brain infarct volume by approximately 54% and 63%, respectively, when compared to vehicle-treated MCAO rats.
2) oxyresveratrol treatment diminished cytochrome c release and decreasedcaspase-3 activation in MCAO rats.

Solubility in organics

Oxyresveratrol is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide, which should be purged with an inert gas. The solubility of oxyresveratrol in these solvents is approximately 50 mg/ml.

Oxyresveratrol(29700-22-9)Related Product Information

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