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PHYSOSTIGMINE SALICYLATE

Basic information Safety Supplier Related

PHYSOSTIGMINE SALICYLATE Basic information

Product Name:
PHYSOSTIGMINE SALICYLATE
Synonyms:
  • PHYSOSTIGMINE SALICYLATE SALT
  • 2-hydroxy-,compd.with(3as-cis)-1,2,3,3a,8,8a-hexahydro-1,3a,8-benzoicaci
  • ar-44
  • ESERINE MONOSALICYLATE
  • ESERINE SALICYLATE
  • ESERINE SALICYLATE SALT
  • ESERINE SALICYLATE 99.9%
  • Physostigmine monosalicylate
CAS:
57-64-7
MF:
C22H27N3O5
MW:
413.47
EINECS:
200-343-8
Product Categories:
  • Inhibitors
  • ANTILIRIUM
  • Alkaloids
  • Biochemistry
  • Indole Alkaloids
Mol File:
57-64-7.mol
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PHYSOSTIGMINE SALICYLATE Chemical Properties

Melting point:
181-183 °C
storage temp. 
-20°C
solubility 
DMF: 30 mg/ml,DMSO: 10 mg/ml,Ethanol: 1 mg/ml,PBS (pH 7.2): 1 mg/ml
pka
pKa 1.96/8.08(H2O,t =15) (Uncertain)
form 
Solid
color 
White to yellow
Merck 
7384
BRN 
3900576
InChI
InChI=1/C15H21N3O2.C7H6O3/c1-15-7-8-17(3)13(15)18(4)12-6-5-10(9-11(12)15)20-14(19)16-2;8-6-4-2-1-3-5(6)7(9)10/h5-6,9,13H,7-8H2,1-4H3,(H,16,19);1-4,8H,(H,9,10)/t13-,15+;/s3
InChIKey
HZOTZTANVBDFOF-DPKVYHSMNA-N
SMILES
C12C=C(C=CC=1N(C)[C@@]1([H])N(CC[C@@]21C)C)OC(=O)NC.C1(C(=O)O)=CC=CC=C1O |&1:8,13,r|
CAS DataBase Reference
57-64-7(CAS DataBase Reference)
EPA Substance Registry System
Physostigmine salicylate (57-64-7)
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Safety Information

Hazard Codes 
T+
Risk Statements 
26/28
Safety Statements 
25-45
RIDADR 
UN 1544 6.1/PG 1
WGK Germany 
3
RTECS 
TJ2450000
HazardClass 
6.1(a)
PackingGroup 
II
HS Code 
2939800000
Toxicity
LD50 i.p. in mice: 0.64 mg/kg (Sofia, Knabloch)

MSDS

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PHYSOSTIGMINE SALICYLATE Usage And Synthesis

Chemical Properties

solid

Uses

Physostigmine salicylate (Eserine salicylate) is used as bulk pharmaceuticals (parasympathomimetic, cholinergic, ophthalmic, anti-Alzheimer). Product Data Sheet

Uses

cholinergic, anticholinesterase, miotic

Definition

ChEBI: Physostigmine salicylate is an azaheterocycle salicylate salt and a member of salicylates. It contains a physostigmine.

brand name

Antilirium (Forest); Isopto Eserine (Alcon).

General Description

The salicylate ofphysostigmine (eserine salicylate) may be prepared byneutralizing an ethereal solution of the alkaloid with anethereal solution of salicylic acid. Excess salicylic acid isremoved from the precipitated product by washing itwith ether. The salicylate is less deliquescent than thesulfate.
Physostigmine salicylate occurs as a white, shining,odorless crystal or white powder that is soluble in water(1:75), alcohol (1:16), or chloroform (1:6) but much lesssoluble in ether (1:250). On prolonged exposure to air andlight, the crystals turn red. The red may be removed bywashing the crystals with alcohol, although this causes lossof the compound as well. Aqueous solutions are neutral orslightly acidic and take on a red coloration after a period.The coloration may be taken as an index of the loss of activityof physostigmine solutions.

General Description

Crystal form that turns red on exposure to heat or light.

Reactivity Profile

Behaves as a weak acid in solution.

Health Hazard

PHYSOSTIGMINE SALICYLATE is similar to physostigmine. It is classified as super toxic. The probable oral lethal dose (humans) is less than 5 mg/kg or a taste for a 150 lb. person. It is a cholinesterase inhibitor.

Fire Hazard

When heated to decomposition, PHYSOSTIGMINE SALICYLATE emits toxic fumes of nitrogen oxides.

Safety Profile

Poison by ingestion, subcutaneous, intramuscular, intravenous, and intraperitoneal routes. Human systemic effects: arrhythmias, nausea or vomiting. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx See also PHYSOSTIGMINE.

PHYSOSTIGMINE SALICYLATESupplier

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