7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one Chemical Properties

Melting point:

233-236 °C

Boiling point:

519.5±60.0 °C(Predicted)

Density 

1.32±0.1 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Solid

pka

7.10±0.10(Predicted)

color 

White to Off-White

InChI

InChI=1S/C16H21N3O4/c1-21-14-10-13-12(16(20)18-11-17-13)9-15(14)23-6-2-3-19-4-7-22-8-5-19/h9-11H,2-8H2,1H3,(H,17,18,20)

InChIKey

WFUBWLXSYCFZEH-UHFFFAOYSA-N

SMILES

N1C2=C(C=C(OCCCN3CCOCC3)C(OC)=C2)C(=O)NC=1

CAS DataBase Reference

199327-61-2(CAS DataBase Reference)

Safety Information

HS Code 

2933599590

7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one Usage And Synthesis

Description

7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one is a pharmaceutical intermediate used in the preparation of gefitinib, an orally active selective inhibitor of the epidermal growth factor receptor tyrosine kinase, an enzyme that regulates intracellular signalling pathways that associated with the proliferation and survival of cancer cells.

Chemical Properties

White Solid

Uses

Gefitinib intermediate.

7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one(199327-61-2)Related Product Information

• Methoxydiethylborane
• m-Anisyl alcohol
• p-Anisidine
• POLY(ETHYLENE GLYCOL) METHYL ETHER ACRYLATE
• 4-Methoxybenzoic acid
• p-Anisaldehyde
• Anisole
• Methoxyacetic acid
• (Trifluoromethoxy)benzene
• Gefitinib-d6
• Gefitinib
• 6-Hydroxy-7-methoxy-3,4-dihydroquinazolin-4-one
• 4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ol
• 2-Amino-4-methoxy-5-(3-morpholinopropoxy)benzonitrile
• 3,4-Dihydro-7-methoxy-4-oxoquinazolin-6-yl acetate
• 4-(3-Chloropropyl)morpholine
• Gefitinib Impurity 11
• 6,7-Dimethoxy-3,4-dihydroquinazoline-4-one