5-Chloro-2-iodopyrimidine Chemical Properties

Boiling point:

316.6±34.0 °C(Predicted)

Density 

2.187±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

pka

-2.56±0.22(Predicted)

form 

Powder

color 

White

Water Solubility 

Slightly soluble in water.

Sensitive 

Light Sensitive

InChI

InChI=1S/C4H2ClIN2/c5-3-1-7-4(6)8-2-3/h1-2H

InChIKey

BWDLBDLGVMLSCS-UHFFFAOYSA-N

SMILES

C1(I)=NC=C(Cl)C=N1

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

HS Code 

2933599590

5-Chloro-2-iodopyrimidine Usage And Synthesis

Description

5-Chloro-2-iodopyrimidine is an organic molecule that belongs to the class of trifluoromethylated molecules. It is a halogenated derivative of pyrimidine and has a molecular formula of C4H2ClIN2. 5-Chloro-2-iodopyrimidine can be catalyzed with copper, which is responsible for its unique reactivity. The synthesis of this molecule has been shown to be efficient in organic chemistry.

Uses

Useful Intermediate for organic synthesis and pharmaceutical.

Preparation

A flask was charged with 57% HI (48 ml) and then cooled to 0°C in an ice-salt mixture. Dichloropyrimidine (6 g) was added to the mixture. After 4h, the obtained yellow suspension was treated carefully with K2CO3 solution (32 g, 60 ml), and the pale yellow solid was collected by filtration. The solid was washed with water and dried to give compound 5-Chloro-2-iodopyrimidine.

Application

As a chemical intermediate used in the pharmaceutical and agrochemical industriesIt, 5-Chloro-2-iodopyrimidine is commonly used as a building block in the synthesis of biologically active molecules, such as kinase inhibitors, antiviral agents, and herbicides.

Origin

5-Chloro-2-iodopyrimidine was discovered by  chemists in 2006 and has been used as a reagent for the efficient trifluoromethylation of organic molecules.