Malonyl chloride Chemical Properties

Boiling point:

53-55 °C/19 mmHg (lit.)

Density 

1.449 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.465(lit.)

Flash point:

117 °F

storage temp. 

2-8°C

solubility 

sol most organic solvents

form 

Liquid

pka

6.86±0.46(Predicted)

color 

Clear yellow to orange to brown

Water Solubility 

decomposes

BRN 

774044

CAS DataBase Reference

1663-67-8(CAS DataBase Reference)

NIST Chemistry Reference

Malonyl dichloride(1663-67-8)

EPA Substance Registry System

Propanedioyl dichloride (1663-67-8)

Safety Information

Hazard Codes 

C

Risk Statements 

14-34-29-10

Safety Statements 

26-36/37/39-45-16

RIDADR 

UN 2920 8/PG 2

WGK Germany 

-

F 

8-10

TSCA 

Yes

HazardClass 

8

PackingGroup 

II

HS Code 

29171990

MSDS

• Language:English Provider:Malonyl chloride
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS

Malonyl chloride Usage And Synthesis

Chemical Properties

clear yellow to orange to brown liquid

Uses

Malonyl Dichloride is primarily used an intermediate in the manufacture of pharmaceutical and agrochemical products.

Uses

Malonyl chloride can be used as a reactant for the synthesis of:

• Alkaloids with tetracyclic cores such as cyclopiamide A and speradine E.
• 6-tetrathiafulvalene(TTF)-polymer by condensation polymerization with TTF-based dihydroxy monomer.
• N-doped TiO₂ films by molecular layer deposition.
• Alkyne-substituted 1,3-oxazines by reaction with arylpropynamides.

It can also be used as a coupling agent in the synthesis of block copolymers by anionic polymerization.

Preparation

Malonyl chloride can be prepared from Malonic Acid and Thionyl Chloride.

Reactions

reacts violently with H2O and protic solvents

storage

Malonyl chloride is unstable at rt and should be used freshly distilled in vacuo or freshly prepared; however, it can be stored in the cold for several days; lachrymatory; use in a fume hood.

Malonyl chloride(1663-67-8)Related Product Information

• Sodium chloride
• Malonamide
• Ammonium chloride
• propanedial
• Barbituric acid
• Acryloyl chloride
• Lauroyl chloride
• Potassium chloride
• Malonic acid
• Benzoyl chloride
• Oxalyl chloride
• Cobalt chloride
• Terephthaloyl chloride
• Tosyl chloride
• Polyvinyl chloride
• Thionyl chloride
• Sulfuryl chloride
• Choline chloride