Ethyl (3-fluorobenzoyl)acetate Chemical Properties

Boiling point:

262-263 °C(lit.)

Density 

1.166 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.5172(lit.)

Flash point:

>230 °F

storage temp. 

Sealed in dry,Room Temperature

form 

Liquid

pka

10.10±0.46(Predicted)

color 

Colorless to orange

CAS DataBase Reference

33166-77-7(CAS DataBase Reference)

Safety Information

WGK Germany 

3

TSCA 

Yes

HS Code 

2916399090

MSDS

• Language:English Provider:SigmaAldrich

Ethyl (3-fluorobenzoyl)acetate Usage And Synthesis

Uses

Reactant for:

• Preparation of biologically active molecules

Synthesis

To a stirring suspension of NaH and CO(OEt)2 in toluene was added dropwise a solution of substituted acetophenone in toluene under reflux. The mixture was allowed to reflux and was stirred for 20 min after the addition was complete. When cooled to room temperature, the mixture was acidified with glacial HOAc. After ice-cold water was added, the mixture was extracted with toluene. The extract was then dried over anhydrous MgS04. After the toluene was evaporated in vacuo to give the corresponding substituted Ethyl (3-fluorobenzoyl)acetate.

Ethyl (3-fluorobenzoyl)acetate(33166-77-7)Related Product Information

• Ethyl 1-ethyl-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate
• 3-(4-FLUORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER
• ETHYL 1,4-DIHYDRO-8-FLUORO-4-OXOQUINOLINE-3-CARBOXYLATE
• 3-(3,4-DIFLUOROPHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER
• Ethyl 2,4,5-trifluorobenzoylacetate
• Ethyl 2,3,4,5-tetrafluorobenzoyl acetate
• 3-(2,4-DICHLORO-5-FLUORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER
• Ethyl (pentafluorobenzoyl)acetate
• 3-(2-FLUORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER
• 5,8-DIFLUORO-4-OXO-1,4-DIHYDRO-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER
• 2-(2,4-DICHLORO-5-FLUORO-BENZOYL)-MALONIC ACID DIETHYL ESTER
• Ethyl 6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate
• (Z)-3-CYCLOPROPYLAMINO-2-(2,4-DICHLORO-5-FLUORO-BENZOYL)-ACRYLIC ACID ETHYL ESTER
• 7-CHLORO-1-CYCLOPROPYL-6-FLUORO-4-OXO-1,4-DIHYDRO-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER
• 2-CYANO-3-(2-FLUORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER
• AKOS 90576
• 5,6,7,8-TETRAFLUORO-2-METHYL-4-OXO-4H-CHROMENE-3-CARBOXYLIC ACID ETHYL ESTER
• AKOS 92524