4-Nitrobenzyl alcohol Chemical Properties

Melting point:

92-94 °C(lit.)

Boiling point:

185 °C12 mm Hg(lit.)

Density 

1.3585 (rough estimate)

refractive index 

1.5030 (estimate)

Flash point:

180 °C

storage temp. 

Sealed in dry,Room Temperature

solubility 

2g/l

pka

13.61±0.10(Predicted)

form 

Crystalline Powder

color 

Yellow

Water Solubility 

Soluble in water (2 mg/ml at 20°C).

BRN 

1424026

Dielectric constant

22.0（20℃）

InChIKey

JKTYGPATCNUWKN-UHFFFAOYSA-N

CAS DataBase Reference

619-73-8(CAS DataBase Reference)

NIST Chemistry Reference

4-NO2-C6H4CH2OH(619-73-8)

EPA Substance Registry System

Benzenemethanol, 4-nitro- (619-73-8)

Safety Information

Hazard Codes 

Xi,C,F,Xn

Risk Statements 

36/37/38-34-11-22

Safety Statements 

22-24/25-36/37/39-26-45-16

WGK Germany 

3

RTECS 

DP0657100

F 

8

Hazard Note 

Irritant

TSCA 

Yes

HS Code 

29062900

MSDS

• Language:English Provider:p-Nitrobenzyl alcohol
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

4-Nitrobenzyl alcohol Usage And Synthesis

Chemical Properties

white to light yellow crystal powde

Uses

4-nitrobenzyl alcohol is used as the sole source of carbon and nitrogen to study the pathway for the catabolism of 4-nitrotoluene by Pseudomonas.

Uses

4-Nitrobenzenemethanol is a potential building block in the synthesis of various pharmaceuticals.

Definition

ChEBI: 4-nitrobenzyl alcohol is a member of the class of benzyl alcohols that is benzyl alcohol substituted at the para-position by a nitro group. It has a role as a xenobiotic metabolite. It is a member of benzyl alcohols and a C-nitro compound.

Synthesis Reference(s)

Organic Syntheses, Coll. Vol. 3, p. 652, 1955
The Journal of Organic Chemistry, 55, p. 2968, 1990 DOI: 10.1021/jo00296a078
Tetrahedron Letters, 19, p. 4985, 1978

Purification Methods

Crystallise the alcohol from EtOH and sublime it in vacuo. Purity should be at least 99.5%. Sublimed samples should be stored in the dark over anhydrous CaSO4 (Drierite). If the IR contains OH bands, then the sample should be resublimed before use. [Mohammed & Kosower J Am Chem Soc 93 2709 1979, Beilstein 6 IV 2611.]

4-Nitrobenzyl alcohol(619-73-8)Related Product Information

• p-Nitrophenylacetonitrile
• 4-Nitrophenylacetic acid
• Ethyl acetate
• 4-Nitrobenzoic acid
• 4-Nitrobenzeneethanol
• 4-Nitrobenzonitrile
• 4-Nitrobenzaldehyde
• 4-Hydroxybenzoic acid
• 3-(4-Hydroxyphenyl)propionic acid
• 4-Bromomethylbenzoic acid
• 4'-Hydroxyacetophenone
• 4-Formylbenzoic acid
• 4-Hydroxycinnamic acid
• 4-Ethoxybenzoic acid
• 4-Nitrobenzophenone
• 4-Nitroacetophenone
• 4-Nitrobenzylamine hydrochloride
• 4-Nitrophthalic acid