1-Methyl-1H-indazol-4-ylamine Chemical Properties

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

form 

solid

color 

Light yellow to brown

Safety Information

HS Code 

2933998090

1-Methyl-1H-indazol-4-ylamine Usage And Synthesis

Synthesis

General procedure for the synthesis of 1-methyl-1H-indazol-4-amine from 1-methyl-4-nitro-1H-indazole: A catalytic amount of 10% palladium carbon was added to a solution of 1-methyl-4-nitro-1H-indazole (0.97 g, 5.5 mmol) in ethanol (50 ml). The resulting mixture was stirred under hydrogen atmosphere for 2 hours. Upon completion of the reaction, the catalyst was removed by filtration followed by evaporation of the solvent. The product was dried by azeotropy with toluene to give 1-methyl-1H-indazol-4-amine as a light brown solid (0.78 g, 96% yield). Mass spectrum (electrospray positive ion mode) m/z: 148 ([M+H]+).

References

[1] Patent: WO2004/46133, 2004, A1. Location in patent: Page 28
[2] Patent: WO2005/28445, 2005, A2. Location in patent: Page/Page column 36
[3] Heterocycles, 2006, vol. 68, # 12, p. 2595 - 2605
[4] Bioorganic and Medicinal Chemistry, 2006, vol. 14, # 14, p. 4740 - 4749
[5] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 17, p. 6025 - 6035

1-Methyl-1H-indazol-4-ylamine(77894-69-0)Related Product Information

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• ETHYL-1-PHENYL-3-ETHYL-4-AMINO-1H-INDAZOLE-5-CARBOXYLATE
• ETHYL 4-AMINO-3-METHYL-1-PHENYL-1H-INDAZOLE-5-CARBOXYLATE
• 4-Amino-1-(tetrahydropyranyl)-1H-indazole
• 1-METHYL-4-(1-METHYLHYDRAZINO)-7-NITRO-1H-INDAZOL-3-AMINE
• 1-Methyl-4-nitro-1H-indazole
• 1-Boc-4-aminoindazole
• 1-Methyl-1H-indazol-4-ylamine