6-CHLORO-IMIDAZO[1,2-B]PYRIDAZINE-3-METHANOL Chemical Properties

storage temp. 

2-8°C

Appearance

Off-white to light brown Solid

6-CHLORO-IMIDAZO[1,2-B]PYRIDAZINE-3-METHANOL Usage And Synthesis

Synthesis

General procedure for the synthesis of 6-chloroimidazo[1,2-b]pyridazine-3-methanol from formaldehyde and 6-chloroimidazo[1,2-b]pyridazine: 1. Preparation of the intermediate 6-chloroimidazo[1,2-b]pyridazine-3-carbaldehyde: To a solution of 6-chloroimidazo[1,2-b]pyridazine (1.5 g, 9.8 mmol) in chloroform (150 mL) was added sodium acetate (1.4 g, 17.1 mmol) and paraformaldehyde (1.5 g). The reaction mixture was heated to reflux overnight. 2. Post-treatment: After completion of the reaction, the mixture was concentrated under reduced pressure. The residue was adjusted to pH=12 with base, filtered and the solid was washed with ethanol to afford 6-chloroimidazo[1,2-b]pyridazine-3-methanol (1.3 g, 72% yield).

References

[1] Patent: WO2011/18454, 2011, A1. Location in patent: Page/Page column 55
[2] Patent: WO2011/20861, 2011, A1. Location in patent: Page/Page column 66

6-CHLORO-IMIDAZO[1,2-B]PYRIDAZINE-3-METHANOL(675580-49-1)Related Product Information

• Imidazo[1,2-b]pyridazine
• 6-CHLORO-3-METHYL-IMIDAZO[1,2-B]PYRIDAZINE
• 6-CHLORO-IMIDAZO[1,2-B]PYRIDAZINE-3-METHANOL
• 6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE-2-CARBOXYLIC ACID