6-CHLORO-3H-PYRIDO[3,4-D]PYRIMIDIN-4-ONE Chemical Properties

Boiling point:

400.8±55.0 °C(Predicted)

Density 

1.66±0.1 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

pka

-1.26±0.20(Predicted)

Appearance

Light brown to brown Solid

Safety Information

HS Code 

2933998090

6-CHLORO-3H-PYRIDO[3,4-D]PYRIMIDIN-4-ONE Usage And Synthesis

Synthesis

5-Amino-2-chloropyridine-4-carboxylic acid (1000 g, 5.8 mol) and formamidine hydrochloride (1867 g, 23.2 mol) were mixed in ethylene glycol monomethyl ether (5000 mL) and sodium acetate (2360 g, 17.4 mol) was added. The reaction mixture was heated to 120 °C and maintained at this temperature for 6 hours. After completion of the reaction, it was cooled to room temperature and the reaction solution was poured into water (4000 mL) and extracted twice with ethyl acetate. The organic phases were combined, dried and concentrated to give the crude product. The crude product was filtered to give 6-chloropyrido[3,4-d]pyrimidin-4(3H)-one (924 g, 5.1 mol).

References

[1] Patent: CN104130256, 2016, B. Location in patent: Paragraph 0027; 0028; 0030

6-CHLORO-3H-PYRIDO[3,4-D]PYRIMIDIN-4-ONE(171178-47-5)Related Product Information

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