2-(2-Fluoro-4-iodoanilino)-3,4-difluorobenzoic Acid Chemical Properties

Melting point:

189-191°C

Boiling point:

370.1±42.0 °C(Predicted)

Density 

1.939±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,2-8°C

solubility 

DMSO (Sparingly), Methanol (Slightly)

form 

Solid

pka

3.25±0.36(Predicted)

color 

Off-White to Beige

Safety Information

HS Code 

2916399090

2-(2-Fluoro-4-iodoanilino)-3,4-difluorobenzoic Acid Usage And Synthesis

Chemical Properties

Off-White Solid

Uses

Intermediate in the preparation of MEK inhibitors.

Synthesis

To a solution of methyl-3,4-diflluoro-2-((2-flluoro-4-iodophenyl)amino)benzoate (23, 6.0 g, 23.8 mmol) in methanol (80 mL) and water (80 mL) was added LiOH (7.8 g, 195 mmol). The reaction mixture was stirred at 78 C in an oil bath for 1 h. After cooling, the reaction mixture was acidified to pH = 2 with a 2 N HCl solution. The solid was filtered and washed with water to provide 2-(2-Fluoro-4-iodoanilino)-3,4-difluoro benzoic Acid (5.11 g, 96%) as a white solid.

2-(2-Fluoro-4-iodoanilino)-3,4-difluorobenzoic Acid(391211-97-5)Related Product Information

• N-(2-FLUOROPHENYL)ANTHRANILIC ACID
• 4-FLUORO-2-PHENYLAMINO-BENZOIC ACID
• 2-Fluoro-4-iodoaniline
• 2-(N-2''-FLURO-4''-IODOPHENYL)AMINO-3,4-DIFLUORO BENZOIC ACID
• 4-Amino-3-chlorophenol
• 3-FLUORODIPHENYLAMINE
• 2-AMINO-3,4-DIFLUOROBENZOIC ACID