6-chloro-2-mercaptoquinazolin-4(3H)-one Chemical Properties

Melting point:

335 °C

Density 

1.60±0.1 g/cm3(Predicted)

pka

8.16±0.20(Predicted)

6-chloro-2-mercaptoquinazolin-4(3H)-one Usage And Synthesis

Uses

SMase-IN-1 (Compound 4) is a bacterial sphingomyelinase enzyme (SMase) inhibitor (IC50 value for B. cereus SMase is 6.43 μM). SMase-IN-1 also inhibits eqBuChE (59.50% inhibition rate at 50 μM concentration). SMase-IN-1 forms a complex with Cu2+ in biometal interactions. SMase-IN-1 reduces B. cereus-induced hemolysis on sheep erythrocytes[1].

References

[1] Ozturk OK, et al. Quinazoline derivatives as novel bacterial sphingomyelinase enzyme inhibitors. Bioorg Chem. 2025 Jan;154:108079. DOI:10.1016/j.bioorg.2024.108079

6-chloro-2-mercaptoquinazolin-4(3H)-one(33017-85-5)Related Product Information

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• 2-(BENZYLSULFANYL)-6-CHLORO-3-(2,4-DICHLORO-5-ISOPROPOXYPHENYL)-4(3H)-QUINAZOLINONE
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• (6,8-DICHLORO-4-OXO-3,4-DIHYDRO-QUINAZOLIN-2-YLSULFANYL)-ACETIC ACID
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• (3-ALLYL-6,8-DICHLORO-4-OXO-3,4-DIHYDRO-QUINAZOLIN-2-YLSULFANYL)-ACETIC ACID
• (6,8-DICHLORO-3-METHYL-4-OXO-3,4-DIHYDRO-QUINAZOLIN-2-YLSULFANYL)-ACETIC ACID
• 6,8-DICHLORO-2-MERCAPTO-3-(3-METHYLBUTANOYL)QUINAZOLIN-4(3H)-ONE
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