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BENACTYZINE HYDROCHLORIDE

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BENACTYZINE HYDROCHLORIDE Basic information

Product Name:
BENACTYZINE HYDROCHLORIDE
Synonyms:
  • 2-(diethylamino)-ethanobenzilatehydrochloride
  • 2-(difenyl-hydroxyacetoxy)ethyl-diethylammoniumchlorid
  • Benactyzine HCL
  • BENACTYZINE HYDROCHLORIDE 98+%
  • BENACTYCIN HYDROCHLORIDE
  • 2-(Diethylamino)ethyl benzilate hydrochloride, Benactyzine, α-Hydroxy-α-phenylbenzeneacetic acid 2-(diethylamino)ethyl ester
  • Amizyl
  • 2-(Difenyl-hydroxyacetoxy)ethyl-diethylammoniumchlorid [czech]
CAS:
57-37-4
MF:
C20H26ClNO3
MW:
363.88
EINECS:
200-324-4
Product Categories:
  • Inhibitors
  • Amines
  • Aromatics
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
Mol File:
57-37-4.mol
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BENACTYZINE HYDROCHLORIDE Chemical Properties

Melting point:
177-179 °C(lit.)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
DMSO (Slightly, Heated), Methanol (Slightly)
form 
Solid
color 
Crystals from Me2CO
Merck 
14,1029
CAS DataBase Reference
57-37-4(CAS DataBase Reference)
EPA Substance Registry System
Benzeneacetic acid, .alpha.-hydroxy-.alpha.-phenyl-, 2-(diethylamino)ethyl ester, hydrochloride (57-37-4)
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Safety Information

Hazard Codes 
T
Risk Statements 
23/24/25
Safety Statements 
36/37/39-45
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
RTECS 
DD2800000
HS Code 
2922.50.4000
HazardClass 
6.1(b)
PackingGroup 
III
Toxicity
LD50 orl-rat: 184 mg/kg TXAPA9 1,42,59

MSDS

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BENACTYZINE HYDROCHLORIDE Usage And Synthesis

Originator

Suavitil,Merck Sharp and Dohme,US,1957

Uses

Benactyzine Hydrochloride is an antagonist of acetylcholine in the central and peripheral nervous system. Benactyzine Hydrochloride is used as an antispasmodic.

Manufacturing Process

114 parts of ethyl benzilate, 175 parts of β-diethylaminoethanol and 0.2 part of metallic sodium were placed in a flask attached to a total-reflux variable take-off fractionating column. The pressure was reduced to 100 mm and heat was applied by an oil bath the temperature of which was slowly raised to 90°C. During three hours of heating 17 parts of ethanol distilled (35.5°C). When the distillation of the ethanol became slow, the bath temperature was raised to 120°C. When the vapor temperature indicated distillation of the amino alcohol the take off valve was closed and the mixture was refluxed for one hour. At the end of this period the vapor temperature had dropped and two more parts of ethanol were distilled, The remaining aminoalcohol was slowly distilled for three hours. The pressure was then reduced to 20 mm and the remainder of the aminoalcohol distilled at 66°C. During the reaction the color of the solution changed from yellow to deep red. The residue was dissolved in 500 parts of ether, washed once with dilute brine, and three times with water, dried over sodium sulfate and finally dried over calcium sulfate. 500 parts of a saturated solution of HCl in absolute ether was added and the resulting precipitate filtered. Dry HCl gas was passed into the filtrate to a slight excess and the precipitate again filtered. The combined precipitates were washed with cold acetone. The 106 parts of product was purified by recrystallization from acetone as fine white crystals which melt at 177°- 178°C.

Therapeutic Function

Tranquilizer; Anticholinergic

Safety Profile

Poison by ingestion, intraperitoneal, subcutaneous, intradermal, and intravenous routes. Human systemic effects by ingestion of very small amounts: toxic psychosis. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of NO, and HCl

BENACTYZINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

BENACTYZINE HYDROCHLORIDESupplier

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