4-(TRIFLUOROMETHYL)-1H-INDOLE Chemical Properties

Boiling point:

256.7±35.0℃ (760 Torr)

Density 

1.367±0.06 g/cm3 (20 ºC 760 Torr)

Flash point:

109.0±25.9℃

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

pka

15.59±0.30(Predicted)

form 

Solid

Appearance

Brown to black Liquid

CAS DataBase Reference

128562-95-8

Safety Information

HS Code 

2933998090

4-(TRIFLUOROMETHYL)-1H-INDOLE Usage And Synthesis

Synthesis

Step 2. Synthesis of 4-trifluoromethyl-1H-indole: Dimethyl-[2-(2-nitro-6-trifluoromethyl-phenyl)-vinyl]-amine (6.3 g, 24 mmol) was dissolved in acetic acid (150 mL) and iron powder (4.3 g, 77 mmol) was added. The reaction mixture was heated to reflux and kept overnight under nitrogen protection. After completion of the reaction, it was cooled to room temperature, the reaction mixture was diluted with 2.0 M hydrochloric acid and the aqueous phase was extracted with ethyl acetate. The organic layer was neutralized with saturated potassium carbonate solution and extracted again. Subsequently, the organic layer was washed sequentially with sodium bicarbonate solution and sodium chloride solution. Finally, the organic layer was dried with magnesium sulfate and concentrated to give 4-trifluoromethyl-1H-indole (4.5 g, 100% yield).

References

[1] Patent: WO2008/60998, 2008, A1. Location in patent: Page/Page column 35-36
[2] Bioscience, Biotechnology and Biochemistry, 2008, vol. 72, # 8, p. 2025 - 2033
[3] Patent: US2013/274253, 2013, A1. Location in patent: Paragraph 2944-2945

4-(TRIFLUOROMETHYL)-1H-INDOLE(128562-95-8)Related Product Information

• 4-(Trifluoromethyl)isoindoline
• 2-PYRIDINECARBOXYLIC ACID, 4-(TRIFLUOROMETHYL)-, METHYL ESTER
• 4-TRIFLUOROMETHYL-BENZAMIDINE HCL
• Pyrimidine, 4-(trifluoromethyl)- (9CI)
• 4-(Trifluoromethyl)benzylboronic acid pinacol ester
• 4-TRIFLUOROMETHYL-PYRIDINE-2-METHANOL
• 2-(4-(trifluoromethyl)phenyl)acetaldehyde
• 4-(Trifluoromethyl)indoline
• C-(4-Trifluoromethyl-pyridin-2-yl)-methylamine
• 4-(TRIFLUOROMETHYL)QUINOLINE
• 2-BROMO-4-(TRIFLUOROMETHYL)PYRIMIDINE
• 7-CHLORO-4-(TRIFLUOROMETHYL)-1H-INDOLE-2-CARBOXYLIC ACID
• 7-CHLORO-4-(TRIFLUOROMETHYL)-1H-INDOLE-2-CARBALDEHYDE
• RARECHEM AN KC 2218
• RARECHEM AN KA 2222
• 4,6-bis(trifluoromethyl)-1H-indole
• RARECHEM AN KB 2227
• RARECHEM AN KD 2237