NAFAMOSTAT MESYLATE Chemical Properties

Boiling point:

586.0±60.0 °C(Predicted)

Density 

1.39±0.1 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

solubility 

Soluble in DMSO

form 

Powder

pka

11.30±0.30(Predicted)

NAFAMOSTAT MESYLATE Usage And Synthesis

Chemical Properties

Odorless, bitter taste. Easily soluble in water, insoluble in methanol, ethanol or dimethylformamide, almost insoluble in ether, chloroform or acetone. Density: 1.39g/cm3; Boiling Point: 637.2°C; Flash Point: 339.1°C; Vapor Pressure: 3.9E-16mmHg.

Uses

Nafamostat is a non-peptide synthetic protease inhibitor with broad-spectrum and potent enzyme inhibition. For the treatment of acute pancreatitis. It can improve acute symptoms of acute pancreatitis, acute exacerbation of chronic pancreatitis, and post-traumatic pancreatitis.

Definition

ChEBI: Nafamostat is a member of benzoic acids and a member of guanidines.

Preparation

6-Bromo-2-naphthol reacts with copper cyanide in dimethylformamide to generate 6-cyano-2-naphthol, which is methanolylated and then aminolyzed to generate 6-amidino-2-naphthol , and finally esterification with p-guanidinobenzoic acid to generate nafamostat.

NAFAMOSTAT MESYLATE(81525-10-2)Related Product Information

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• NAFAMOSTAT MESYLATE