Basic information Safety Supplier Related

H-1152Glycyl, Dihydrochloride

Basic information Safety Supplier Related

H-1152Glycyl, Dihydrochloride Basic information

Product Name:
H-1152Glycyl, Dihydrochloride
Synonyms:
  • (2S)-4-(Aminoacetyl)hexahydro -2-methyl-1-[(4-methyl-5-isoquinolinyl)sulfonyl]-1H-1,4-diazepine Dihydrochloride
  • 2-Amino-1-[(3S)-hexahydro-3-methyl-4-[(4-methyl-5-isoquinolinyl)sulfonyl]-1H-1,4-diazepin-1-yl]ethanone Hydrochloride
  • (S)-(+)-4-Glycyl-2-methyl-1-[(4-methyl-5-isoquinolinyl) sulfonyl]-hexahydro-1H-1,4-diazepine dihydrochloride
  • (S)-Glycyl-H-1152 (hydrochloride)
  • Glycyl-H 1152 2HCl
  • Rho Kinase Inhibitor IV
  • H-1152Glycyl, Dihydrochloride
  • Glycyl H-1152 hydrochloride
CAS:
913844-45-8
MF:
C18H26Cl2N4O3S
MW:
0
Product Categories:
  • All Inhibitors
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Protein Kinase Inhibitors and Activators
  • Protein Kinase
Mol File:
913844-45-8.mol
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H-1152Glycyl, Dihydrochloride Chemical Properties

Melting point:
190-192°C
storage temp. 
Refrigerator
solubility 
Methanol (Slightly), Water (Slightly)
form 
Solid
color 
Pale Yellow to Beige
Stability:
Hygroscopic
CAS DataBase Reference
913844-45-8
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H-1152Glycyl, Dihydrochloride Usage And Synthesis

Chemical Properties

Pale-Yellow Solid

Uses

A glycyl analog of Rho-kinase (ROCK) inhibitor that inhibits ROCK with an improved selectitity; for treatment of hypertension and arteriosclerosis.

Biological Activity

Glycyl analog of the Rho-kinase inhibitor H 1152 dihydrochloride ((S)-(+)-2-Methyl-1-[(4-methyl-5-isoquinolinyl)sulfonyl]-hexahydro-1H-1,4-diazepine dihydrochloride ) that displays improved ROCKII selectivity. IC 50 values are 0.0118, 2.35, 2.57, 3.26, > 10 and >10 μ M for ROCKII, Aurora A, CAMKII, PKG, PKA and PKC respectively.

storage

room temperature (desiccate)

H-1152Glycyl, DihydrochlorideSupplier

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