H-1152Glycyl, Dihydrochloride
H-1152Glycyl, Dihydrochloride Basic information
- Product Name:
- H-1152Glycyl, Dihydrochloride
- Synonyms:
-
- (2S)-4-(Aminoacetyl)hexahydro -2-methyl-1-[(4-methyl-5-isoquinolinyl)sulfonyl]-1H-1,4-diazepine Dihydrochloride
- 2-Amino-1-[(3S)-hexahydro-3-methyl-4-[(4-methyl-5-isoquinolinyl)sulfonyl]-1H-1,4-diazepin-1-yl]ethanone Hydrochloride
- (S)-(+)-4-Glycyl-2-methyl-1-[(4-methyl-5-isoquinolinyl) sulfonyl]-hexahydro-1H-1,4-diazepine dihydrochloride
- (S)-Glycyl-H-1152 (hydrochloride)
- Glycyl-H 1152 2HCl
- Rho Kinase Inhibitor IV
- H-1152Glycyl, Dihydrochloride
- Glycyl H-1152 hydrochloride
- CAS:
- 913844-45-8
- MF:
- C18H26Cl2N4O3S
- MW:
- 0
- Product Categories:
-
- All Inhibitors
- Inhibitors
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Protein Kinase Inhibitors and Activators
- Protein Kinase
- Mol File:
- 913844-45-8.mol
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H-1152Glycyl, Dihydrochloride Chemical Properties
- Melting point:
- 190-192°C
- storage temp.
- Refrigerator
- solubility
- Methanol (Slightly), Water (Slightly)
- form
- Solid
- color
- Pale Yellow to Beige
- Stability:
- Hygroscopic
- CAS DataBase Reference
- 913844-45-8
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H-1152Glycyl, Dihydrochloride Usage And Synthesis
Chemical Properties
Pale-Yellow Solid
Uses
A glycyl analog of Rho-kinase (ROCK) inhibitor that inhibits ROCK with an improved selectitity; for treatment of hypertension and arteriosclerosis.
Biological Activity
Glycyl analog of the Rho-kinase inhibitor H 1152 dihydrochloride ((S)-(+)-2-Methyl-1-[(4-methyl-5-isoquinolinyl)sulfonyl]-hexahydro-1H-1,4-diazepine dihydrochloride ) that displays improved ROCKII selectivity. IC 50 values are 0.0118, 2.35, 2.57, 3.26, > 10 and >10 μ M for ROCKII, Aurora A, CAMKII, PKG, PKA and PKC respectively.
storage
room temperature (desiccate)
H-1152Glycyl, DihydrochlorideSupplier
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