2-Benzylamino-2-methyl-1-propanol Chemical Properties

Melting point:

68-70℃

Boiling point:

300.8±17.0 °C(Predicted)

Density 

1.006±0.06 g/cm3(Predicted)

storage temp. 

2-8°C(protect from light)

solubility 

Chloroform, DMSO, Methanol

form 

Solid

pka

14.55±0.10(Predicted)

color 

Off-White

InChI

InChI=1S/C11H17NO/c1-11(2,9-13)12-8-10-6-4-3-5-7-10/h3-7,12-13H,8-9H2,1-2H3

InChIKey

JIDHEIXSIHNMCG-UHFFFAOYSA-N

SMILES

C(O)C(C)(NCC1=CC=CC=C1)C

CAS DataBase Reference

10250-27-8

2-Benzylamino-2-methyl-1-propanol Usage And Synthesis

Chemical Properties

Yellow-Orange Solid

Synthesis Reference(s)

Tetrahedron, 44, p. 6801, 1988 DOI: 10.1016/S0040-4020(01)86206-2

Synthesis

To a solution of 2-amino-2-methylpropan-1-ol (1 g, 11.22 mmol) and benzaldehyde (1.310 g, 12.34 mmol) in DCE (15 mL) at RT was added portionwise sodium triacetoxyborohydride (6.66 g, 31.4 mmol), and the mixture was stirred for 3 h. The mixture was diluted with EtOAc and washed with saturated aqueous NaHCO3. The organic layer was dried over MgSO4, filtered, and concentrated. The crude product 2-Benzylamino-2-methyl-1-propanol (1.247 g, 6.96 mmol, 62 % yield) was used without further purification. LCMS (m/z): 180.0 (M+H+).

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