Chloromethyl chlorosulfate Chemical Properties

Boiling point:

45-50 °C/10 mmHg

Density 

1.631 g/mL at 25 °C

refractive index 

n 20/D 1.448

Flash point:

176 °F

storage temp. 

2-8°C

solubility 

soluble in Chloroform, Ethyl Acetate

form 

Liquid

color 

Clear colorless to yellow

Water Solubility 

reacts

Stability:

Moisture Sensitive

InChI

InChI=1S/CH2Cl2O3S/c2-1-6-7(3,4)5/h1H2

InChIKey

PJBIHXWYDMFGCV-UHFFFAOYSA-N

SMILES

S(Cl)(OCCl)(=O)=O

CAS DataBase Reference

49715-04-0(CAS DataBase Reference)

Safety Information

Hazard Codes 

C,T+

Risk Statements 

22-34-26

Safety Statements 

26-36/37/39-45-28A

RIDADR 

UN 1760 8/PG 3

WGK Germany 

3

HazardClass 

8

PackingGroup 

II

HS Code 

29049090

Storage Class

5.1B - Oxidizing hazardous materials

Hazard Classifications

Acute Tox. 1 Inhalation
Acute Tox. 4 Oral
Carc. 1A
Skin Corr. 1B

MSDS

• Language:English Provider:Chloromethyl chlorosulfate
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS

Chloromethyl chlorosulfate Usage And Synthesis

Chemical Properties

Clear colourless to yellow liquid

Uses

Reagent for chloromethylation of Fmoc-protected amino acids without the generation of carcinogenic bis(chloromethyl)ether.

Synthesis

1) reacting liquid sulfur trioxide with methylene chloride for 1 to 24 hours at -50 to 40?? C. in the presence of a catalyst carbonate, a saturated hydrocarbon base carbonate containing saturated hydrocarbon base, a borate salt, and a borate containing saturated hydrocarbon base to produce a mixture of chloromethyl chlorosulfonate and methyldichlorosulfonate;

2) putting sodium bicarbonate or an aqueous sodium bicarbonate solution into the mixture obtained from step 1) above to remove the excessive amount of Sulfur trioxide and the sulfuric acid produced by hygroscopicity, so that the reaction continues;

3) put sodium bicarbonate or an aqueous sodium bicarbonate solution into the mixture obtained in step 2) above, completely remove the excessive sulfur trioxide and the sulfuric acid produced by hygroscopicity, static layering, take the upper organic layer to dry to remove the solvent and distill under reduced pressure, to obtain chloromethyl chlorosulfonate and methyldichlorosulfonate, respectively.

Chloromethyl chlorosulfate(49715-04-0)Related Product Information

• Chloromethyl isobutyrate
• Chloromethyl isopropyl carbonate
• Ethyl malonyl chloride
• 2-CHLORO-2-HYDROXYIMINOACETIC ACID ETHYL ESTER
• 9-Fluorenylmethyl chloroformate
• ChloroMethyl Methyl Carbonate
• Tetrabutylammonium hydrogen sulfate
• 2-CHLOROETHANESULFONYL CHLORIDE
• 2-Chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride
• Chlorosulfonic acid
• Chloromethyl methyl ether
• Methyl chlorosulfonate
• Chloromethyl chlorosulfate