2,3-DIOXOINDOLINE-7-CARBOXYLIC ACID Chemical Properties

Melting point:

268 °C

Density 

1.591±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

form 

crystalline powder

pka

2.66±0.20(Predicted)

color 

Orange

CAS DataBase Reference

25128-35-2(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,T

Risk Statements 

36/37/38-25

Safety Statements 

26-36/37/39-37/39-45

Hazard Note 

Irritant

HS Code 

2934999090

2,3-DIOXOINDOLINE-7-CARBOXYLIC ACID Usage And Synthesis

Synthesis

Step I. Synthesis of 2,3-dioxoindoline-7-carbonitrile

To a 100 ml three-necked flask equipped with a stirrer, a thermometer and a reflux condenser tube was added 2,3-dioxoindoline-7-carbaldehyde, hydroxylamine hydrochloride, sodium acetate, 30 mL of glacial acetic acid and 1 mL of acetic anhydride, and refluxed to react. After cooling, it was poured into ice water to precipitate a solid, filtered, washed with water and dried, and recrystallized to obtain 2,3-dioxoindoline-7-carbonitrile.

Step II, Synthesis of 2,3-dioxoindoline-7-carboxylic acid

To a 100 ml three-necked flask equipped with a stirrer, a thermometer and a reflux condenser tube was added 2,3-dioxoindoline-7-carbonitrile, NaOH, water, and refluxed to react. After cooling and filtration, the filtrate was acidified with dilute hydrochloric acid to pH<3, a solid was precipitated, filtered and dried to obtain the compound 2,3-dioxoindoline-7-carboxylic acid.

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