1-Benzylimidazole Chemical Properties

Melting point:

68-70 °C(lit.)

Boiling point:

310 °C(lit.)

Density 

1.2419 (rough estimate)

refractive index 

1.6392 (estimate)

storage temp. 

Sealed in dry,Room Temperature

solubility 

DMF: >530 μg/ml; DMSO: >560 μg/ml; Ethanol: >500 μg/ml; PBS pH 7.2: >6.5 mg/ml

pka

6.79±0.10(Predicted)

form 

Crystals

color 

Brownish

Water Solubility 

insoluble

λmax

215nm(EtOH)(lit.)

BRN 

114571

InChI

1S/C10H10N2/c1-2-4-10(5-3-1)8-12-7-6-11-9-12/h1-7,9H,8H2

InChIKey

KKKDZZRICRFGSD-UHFFFAOYSA-N

SMILES

C(c1ccccc1)n2ccnc2

CAS DataBase Reference

4238-71-5(CAS DataBase Reference)

NIST Chemistry Reference

1H-Imidazole, 1-(phenylmethyl)-(4238-71-5)

Safety Information

Risk Statements 

36/37/38

Safety Statements 

22-24/25

WGK Germany 

3

F 

10

HS Code 

29332900

Storage Class

11 - Combustible Solids

MSDS

• Language:English Provider:1-Benzylimidazole
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

1-Benzylimidazole Usage And Synthesis

Chemical Properties

BROWNISH CRYSTALS

Uses

1-Benzylimidazole acts as an inducer of various cytochrome P-450 isozymes and inhibitor of thromboxane A2 synthase. 1-Benzylimidazole has been used to prepare cyclodextrin-ionic liquid polymer (βCD-BIMOTs-TDI)

Uses

Sodium thiosulfate pentahydrate may be involved in the estimation of iodide in pharmaceutical samples, using spectrophotometric method.

Synthesis Reference(s)

Journal of the American Chemical Society, 71, p. 383, 1949 DOI: 10.1021/ja01170a002

General Description

1-Benzylimidazole has been used to prepare cyclodextrin-ionic liquid polymer (βCD-BIMOTs-TDI).

Biochem/physiol Actions

1-Benzylimidazole is a CYP inhibitor that inhibits the biotransformation of MeO-BDEs (methoxylated-brominated diphenyl ethers) to OH-BDEs (hydroxylated) in fishes.

Synthesis

First, 8.35g concentration of 36% formaldehyde aqueous solution and 18.1g concentration of 32% glyoxal aqueous solution was added to 250mL three-necked flask, stirring and heating to 50 ?? reflux, and then 6.05g concentration of 28% of ammonia and benzylamine methanol solution (dosage of 10.7g of benzylamine dissolved in 50mL methanol) was added to the three-necked flask drop by drop, add the end of the reaction continue to reflux 4h, evaporated methanol, poured into ice water, extracted with ethyl acetate, and then concentrated by rotary evaporation at 40 ??, and then vacuum dried at 60 ?? for 24h to obtain light yellow N-benzyl imidazole solid, the yield was about 75%.

1-Benzylimidazole(4238-71-5)Related Product Information

• Benzyltriethylammonium chloride
• 1-Methylimidazole
• Imidazole
• Benzyl bromide
• Benzyltrimethylammonium chloride
• Benzyl alcohol
• Benzyl benzoate
• Dibenzylideneacetone
• N,N-Dimethylbenzylamine
• BENZYL GLYCIDYL ETHER
• Benzyl chloride
• 4-Acryloylmorpholine
• 1-BENZYL-2-(CHLOROMETHYL)-1H-IMIDAZOLE HCL
• N-Boc-1-phenylmethyl-D-histidine
• Z-HIS(BZL)-OH
• N-PENTAFLUOROBENZOYLIMIDAZOLE
• 1-DODECYL-2-METHYL-3-BENZYLIMIDAZOLIUM CHLORIDE
• Phenylacetone