Tetrakis(hydroxymethyl)phosphonium chloride Chemical Properties

Melting point:

154°C

Boiling point:

115°C/760mmHg

Density 

1.341 g/mL at 25 °C

vapor pressure 

0Pa at 25℃

refractive index 

n20/D 1.512

form 

Solution

pka

6.05[at 20 ℃]

color 

Clear light pink or yellow-green

Water Solubility 

>=10 g/100 mL at 20 ºC

BRN 

3631669

InChI

InChI=1S/C4H12O4P.ClH/c5-1-9(2-6,3-7)4-8;/h5-8H,1-4H2;1H/q+1;/p-1

InChIKey

AKXUUJCMWZFYMV-UHFFFAOYSA-M

SMILES

[P+](CO)(CO)(CO)CO.[Cl-]

LogP

-9.8

CAS DataBase Reference

124-64-1(CAS DataBase Reference)

EPA Substance Registry System

Tetrakis(hydroxymethyl)phosphonium chloride (124-64-1)

Safety Information

Hazard Codes 

T,N

Risk Statements 

21-25-38-41-42/43-51/53

Safety Statements 

22-26-36/37/39-45-60-61-23

RIDADR 

UN 2810 6.1/PG 3

WGK Germany 

3

RTECS 

TA2450000

HazardClass 

8

PackingGroup 

III

HS Code 

29319019

Hazardous Substances Data

124-64-1(Hazardous Substances Data)

Toxicity

mammal (species unspecified),LD50,oral,400mg/kg (400mg/kg),Kobunshi. High Polymers. Vol. 24, Pg. 788, 1975.

MSDS

• Language:English Provider:Tetrakis(hydroxymethyl)phosphonium chloride
• Language:English Provider:SigmaAldrich

Tetrakis(hydroxymethyl)phosphonium chloride Usage And Synthesis

Chemical Properties

Clear light pink or yellow-green solution

Uses

Flame-retarding agent for cotton fabrics. May be used in combination with triethylolamine and urea (Roxel process) or with triethanolamine and tris(1-aziridinyl) phosphine oxide.

Uses

Tetrakis(hydroxymethyl)phosphonium chloride solution (80% in H₂O) has been used as a reducing agent and stabilizing ligand for the synthesis of gold nanoparticles (AuNPs) from gold(III) chloride trihydrate (HAuCl₄.3H₂O). It is a tetra-functional, amine-reactive, aqueous crosslinker that can be used for tuning the properties of protein-based hydrogels for 3D cell encapsulation applications.

Definition

A crystalline compound made by the reaction of phosphine, formaldehyde, and hydrochloric acid.

General Description

Clear slightly viscous,colorless to yellow liquid (20% H2O solution).

Air & Water Reactions

Hygroscopic. Water soluble.

Reactivity Profile

Tetrakis(hydroxymethyl)phosphonium chloride reacts vigorously with oxidizers and alkalis. Reacts with cellulose.

Health Hazard

ACUTE/CHRONIC HAZARDS: Tetrakis(hydroxymethyl)phosphonium chloride may be corrosive. When heated to decomposition, it may emit very toxic fumes of POx, hydrogen chloride and bis(chloromethyl)ether. Decomposition of Tetrakis(hydroxymethyl)phosphonium chloride in an aqueous environment may produce phosphine, formaldehyde and hydrogen chloride.

Fire Hazard

Tetrakis(hydroxymethyl)phosphonium chloride is probably combustible.

Flammability and Explosibility

Non flammable

Purification Methods

Crystallise it from AcOH and dry it at 100o in a vacuum. An 80% w/v aqueous solution has d4 1.33 [Reeves J Am Chem Soc 77 3923 1955]. [Beilstein 1 IV 3062.]

Tetrakis(hydroxymethyl)phosphonium chloride (124-64-1)Related Product Information

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