ChemicalBook > Product Catalog > Biochemical Engineering > Polypeptide > H-TYR-D-ALA-GLY-PHE-D-LEU-OH
H-TYR-D-ALA-GLY-PHE-D-LEU-OH
H-TYR-D-ALA-GLY-PHE-D-LEU-OH Basic information
- Product Name:
- H-TYR-D-ALA-GLY-PHE-D-LEU-OH
- Synonyms:
-
- YAGFL
- TYR-D-ALA-GLY-PHE-D-LEU
- TYR-D-ALA-GLY-PHE-D-LEU ACOH H2O
- H-TYR-D-ALA-GLY-PHE-D-LEU-OH
- (D-ALA2,D-LEU5)-ENKEPHALIN
- [D-ALA2,D-LEU5]-ENKEPHALIN ACOH H2O
- DADLE
- Enkephalin, Leucine-2-Alanine
- CAS:
- 63631-40-3
- MF:
- C29H39N5O7
- MW:
- 569.65
- Product Categories:
-
- peptide
- Mol File:
- 63631-40-3.mol
More
Less
H-TYR-D-ALA-GLY-PHE-D-LEU-OH Chemical Properties
- Melting point:
- >167°C (dec.)
- Boiling point:
- 991.9±65.0 °C(Predicted)
- Density
- 1.257±0.06 g/cm3(Predicted)
- storage temp.
- -15°C
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- 3.40±0.10(Predicted)
- form
- Solid
- color
- White to Off-White
- Water Solubility
- Soluble to 1 mg/ml in water
- Stability:
- Hygroscopic
More
Less
H-TYR-D-ALA-GLY-PHE-D-LEU-OH Usage And Synthesis
Uses
DADLE is a selective δ-?OR agonist.
in vivo
BW-180C ( [D-Ala2, D-Leu5]-Enkephalin; DADLE) protects liver against ischemia-reperfusion injury in the rat. DADLE (5 mg/kg) protects the heart, lung, and jejunum against ischemia-reperfusion (I-R) injury[2].
BW-180C (DADLE) improves hepatic ischemia/reperfusion injury in mice via activation of the Nrf2/HO1 pathway[3].
DADLE (5 mg/kg) significantly reduces the levels of alanine aminotransferase and aspartate aminotransferase in the serum, and the levels of malondialdehyde in the liver homogenate[3].
| Animal Model: | Male Wistar rats weighing 200 to 250 g[2] |
| Dosage: | 5 mg/kg |
| Administration: | Administered intravenously into the inferior vena cava |
| Result: | After 120 min of reperfusion, the serum GPT levels were significantly lower in the DADLE group than in the Control group. |
| Animal Model: | Male C57BL/6 mice (age, 35-42 days; weight, 18-22 g; 6 mice in each group)[3] |
| Dosage: | 5 mg/kg |
| Administration: | Injected intraperitoneally 15 min prior to I/R |
| Result: | The serum levels of AST and ALT in the serum DADLE group were significantly lower. |
storage
Store at -20°C
H-TYR-D-ALA-GLY-PHE-D-LEU-OHSupplier
3B Pharmachem (Wuhan) International Co.,Ltd.
- Tel
- 821-50328103-801 18930552037
- 3bsc@sina.com
GL Biochem (Shanghai) Ltd
- Tel
- 21-61263452 13641803416
- ymbetter@glbiochem.com
Shanghai Hanhong Scientific Co.,Ltd.
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
Chemsky (shanghai) International Co.,Ltd
- Tel
- 021-50135380
- shchemsky@sina.com
Wuxi Zhongkun Biochemical Technology Co., Ltd.
- Tel
- 0510-85629785 18013409632
- sales@reading-chemicals.com