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Boldine

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Boldine Basic information

Product Name:
Boldine
Synonyms:
  • (+)-(s)-boldine
  • (s)-boldine
  • (s)-yl
  • 1,10-dimethoxy-6a-alpha-aporphine-2,9-diol
  • 1,10-dimethoxy-6a-alpha-aporphine-9-diol
  • 4h-dibenzo(de,g)quinoline-2,9-diol,5,6,6a,7-tetrahydro-1,10-dimethoxy-6-meth
  • 4h-dibenzo[de,g]quinoline-2,9-diol,5,6,6a,7-tetrahydro-1,10-dimethoxy-6-methyl
  • boldin
CAS:
476-70-0
MF:
C19H21NO4
MW:
327.37
EINECS:
207-509-9
Mol File:
476-70-0.mol
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Boldine Chemical Properties

Melting point:
162-164 °C
Boiling point:
465.27°C (rough estimate)
Density 
1.2223 (rough estimate)
refractive index 
1.5000 (estimate)
storage temp. 
2-8°C
solubility 
Acetonitrile (Slightly), Ethyl Acetate (Slightly, Heated), Methanol (Slightly)
form 
Solid
pka
9.75±0.20(Predicted)
color 
Yellow to Dark Brown
Merck 
13,1316
BRN 
94036
LogP
0.837 (est)
CAS DataBase Reference
476-70-0(CAS DataBase Reference)
EPA Substance Registry System
4H-Dibenzo[de,g]quinoline-2,9-diol, 5,6,6a,7-tetrahydro-1,10-dimethoxy-6-methyl-, (6aS)- (476-70-0)
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Safety Information

Hazard Codes 
Xn
Risk Statements 
22-36/37/38
Safety Statements 
1-20-24/25-45-36-26
RIDADR 
1544
WGK Germany 
3
RTECS 
CE0750000
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29399990

MSDS

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Boldine Usage And Synthesis

Chemical Properties

White powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Linderae odorata.

Uses

antineoplastic

Uses

boldine is attributed with strong anti-oxidant properties. It has also demonstrated an ability to protect against uVB rays. Boldine is a constituent of the boldo plant (Peumus boldus Mol.) native to Chile, and is found in the plant’s leaves and bark.

Definition

ChEBI: Boldine is an aporphine alkaloid.

in vivo

Boldine (50 mg/kg, p.o, for 7 days) attenuates Dextran Sulfate Sodium (DSS) -induced colitis in mice via p65-NF-κB and STAT3 signaling pathways[3].

Animal Model:DSS-induced mice model[3]
Dosage:50 mg/kg
Administration:p.o.
Result: Reduced the expression of CD 68+ and activity of myeloperoxidase (MPO)
Attenuated Pro-Inflammatory Cytokines and the level of malondialdehyde (MDA)
Increased the Activities of Enzymic Antioxidants and Inhibited p65-NF-κB and STAT3 Activity.

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