2-(1-Piperazinyl)pyrimidine Chemical Properties

Melting point:

32-34°C

Boiling point:

277 °C (lit.)

Density 

1.158 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.587(lit.)

Flash point:

>230 °F

storage temp. 

2-8°C

solubility 

Chloroform (Slightly), Methanol (Slightly)

form 

Liquid After Melting

pka

8.68±0.10(Predicted)

color 

Clear yellow

Water Solubility 

almost transparency

Sensitive 

Hygroscopic

BRN 

151178

InChIKey

MRBFGEHILMYPTF-UHFFFAOYSA-N

CAS DataBase Reference

20980-22-7(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36-24/25

WGK Germany 

3

RTECS 

UV9702000

TSCA 

Yes

HazardClass 

8

HS Code 

29335990

MSDS

• Language:English Provider:1-(2-Pyrimidyl)piperazine
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

2-(1-Piperazinyl)pyrimidine Usage And Synthesis

Chemical Properties

clear yellow liquid after melting

Uses

2-(1-Piperazinyl)pyrimidine (Buspirone EP Impurity A) is the major metabolite of Tandospirone (T006430).

Uses

The major metabolite of Tandospirone.

Definition

ChEBI: 1-(2-Pyrimidyl)piperazine is a N-arylpiperazine.

Synthesis Reference(s)

The Journal of Organic Chemistry, 18, p. 1484, 1953 DOI: 10.1021/jo50017a004

General Description

1-(2-Pyrimidyl)piperazine is a piperazine-based derivative. It is a metabolite of buspirone.

2-(1-Piperazinyl)pyrimidine(20980-22-7)Related Product Information

• 2-Ethylhexyl ferulate
• Piperazine
• Piperacillin
• 1-Methylpiperazine
• N-Aminoethylpiperazine
• Homopiperazine
• 2-Chloropyrimidine
• Dihydrochloride
• BUSPIRONE (D8)
• 3,3-Tetramethyleneglutarimide
• Buspirone EP Impurity F
• 8-(pyrimidin-2-yl)-5,8-diazaspiro[4.5]decan-5-ium chloride
• Buspirone Impurity 1 (Lactone of 6-Hydroxy Buspirone)
• 8-(4-Chlorobutyl)-8-azaspiro[4.5]decane-7,9-dione
• Buspirone EP Impurity H
• Buspirone Impurity 2
• Buspirone N-Oxide
• Buspirone impurity 3