(R)-(-)-1-Cyclohexylethylamine Chemical Properties

Melting point:

-15°C (estimate)

alpha 

-3.8 º (NEAT)

Boiling point:

177-178 °C (lit.)

Density 

0.866 g/mL at 20 °C (lit.)

refractive index 

n20/D 1.463

Flash point:

126 °F

pka

10.89±0.29(Predicted)

form 

clear liquid

color 

Colorless to Almost colorless

optical activity

[α]20/D 4°, neat &_& [α]20/D -3.8±0.3°, neat

Water Solubility 

Miscible with acetone, chloroform,dimethyl sulfoxide, ethanol, methanol, ether, petroleum ether and dichloromethane. Insoluble in water.

Sensitive 

Air Sensitive

BRN 

2935070

CAS DataBase Reference

5913-13-3(CAS DataBase Reference)

NIST Chemistry Reference

R-(-)-Cyclohexylethylamine(5913-13-3)

Safety Information

Hazard Codes 

C

Risk Statements 

10-21/22-34

Safety Statements 

26-36/37/39-45

RIDADR 

UN 2734 8/PG 2

WGK Germany 

3

F 

3-10-23

HazardClass 

8

PackingGroup 

II

HS Code 

2921309990

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

(R)-(-)-1-Cyclohexylethylamine Usage And Synthesis

Chemical Properties

optical purity >99% ee

Uses

(R)-(-)-1-Cyclohexylethylamine is used in the preparation of benzylidene(1-cyclohexylethyl)amine by reacting with benzaldehyde. It is also used to prepare chiral polymethacrylamides, which are employed as stationary phases for the liquid-chromatographic resolution of racemic amides. In addition to this, it is used in the preparation of polyamides bound to silica gel for high performance liquid chromatography, which are pressure-stable.

Uses

(R)-(-)-1-Cyclohexylethylamine may be used in the preparation of a chiral calix[4]arene Schiff base derivatives with potential enantioselective recognition ability towards amines.

General Description

(R)-(-)-1-Cyclohexylethylamine is a chiral amine mainly used as a resolving agent for racemic compounds.

Purification Methods

Purify it by conversion to the bitartrate salt (m 172o), then decomposing with strong alkali and extracting into Et2O, drying (KOH), filtering, evaporating and distilling. The hydrochloride salt has m 242o (from EtOH/Et2O), [] D -5.0o (c 10 H2O, from (+) amine). The oxalate salt has m 132o (from H2O). The (±)-base has b 176-178o/760mm, and HCl has m 237-238o. [Reihlen et al. Justus Liebigs Ann Chem 532 247 1938, Leithe Chem Ber 65 660 1932, Beilstein 12 III 95.]

(R)-(-)-1-Cyclohexylethylamine(5913-13-3)Related Product Information

• Isocyanatocyclohexane
• Cyclohexanecarboxylic acid
• Cyclamic acid
• Cyclohexylbenzene
• Molasses
• Diethylstilbestrol
• Cyclohexanemethanol
• OXYMORPHONE
• 1,8-DIAMINO-P-MENTHANE
• Naloxone hydrochloride
• 2-Adamantanamine hydrochloride
• 2-AMINOADAMANTANE
• CONDELPHINE
• Naltrexone hydrochloride
• HYDROCODONE BITARTRATE
• (S)-(+)-1-Cyclohexylethylamine
• 2-CYCLOHEXYLETHYLAMINE HYDROCHLORIDE ---CRYSTALLINE---
• L-alpha-Cyclohexylglycine