Ethyl 3-aminopropanoate hydrochloride Chemical Properties

Melting point:

67-70 °C(lit.)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

form 

Crystalline Powder

color 

White to off-white

Water Solubility 

almost transparency

Sensitive 

Hygroscopic

BRN 

3559095

InChI

InChI=1S/C5H11NO2.ClH/c1-2-8-5(7)3-4-6;/h2-4,6H2,1H3;1H

InChIKey

RJCGNNHKSNIUAT-UHFFFAOYSA-N

SMILES

C(=O)(OCC)CCN.Cl

CAS DataBase Reference

4244-84-2(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

36/37/39-26-22-36-24/25

WGK Germany 

3

HazardClass 

HYGROSCOPIC

HS Code 

29224995

MSDS

• Language:English Provider:beta-Alanine ethyl ester hydrochloride
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

Ethyl 3-aminopropanoate hydrochloride Usage And Synthesis

Chemical Properties

White to off-white crystalline powder

Uses

peptide synthesis

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

Freshly distilled thionyl chloride (250 mL) was slowly added dropwise to stirred anhydrous ethanol (400 mL) at -10 °C. After maintaining the reaction at -10 °C for 20 min, β-alanine (82.56 g, 0.93 mol) was slowly added to the thionyl chloride/ethanol mixture. The reaction mixture was heated to reflux for 2 hours. Upon completion of the reaction, the excess thionyl chloride was removed by distillation and the reaction solution was concentrated to half of the original volume under reduced pressure. The white precipitate precipitated from the concentrate was collected by filtration and washed with cold ether to give a final white crystalline powder of β-alanine ethyl ester hydrochloride (124.34 g, 87% yield).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 19, p. 6200 - 6204
[2] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 6, p. 2336 - 2350
[3] European Journal of Medicinal Chemistry, 2011, vol. 46, # 1, p. 11 - 20
[4] Journal of Heterocyclic Chemistry, 2013, vol. 50, # 5, p. 1067 - 1070
[5] Russian Chemical Bulletin, 2017, vol. 66, # 1, p. 136 - 142

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